II. Indication

  1. Highly specific for Systemic Lupus Erythematosus

III. Causes: Negative

  1. Normal

IV. Causes: Positive (percentage refers to Test Sensitivity)

  1. Systemic Lupus Erythematosus
    1. Associated with Lupus Nephritis
    2. Associated with Lupus CNS Involvement
    3. May correlate with disease activity in some patients (esp. Lupus Nephritis)
    4. Test Sensitivity for SLE: 70%
    5. Test Specificity for SLE: 95%
  2. Sjogren's Syndrome (5%)
  3. Rheumatoid Arthritis (<5%)
  4. Chronic active hepatitis
  5. Biliary Cirrhosis
  6. Epstein Barr Virus
  7. Cytomegalovirus

V. References

  1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
  2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
  3. Ali (2018) Am Fam Physician 98(3): 164-70 [PubMed]
  4. Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed]
  5. Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed]

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Ontology: Antibody to double stranded DNA measurement (C0201350)

Concepts Laboratory Procedure (T059)
SnomedCT 122225004, 87978006, 143307005, 165921007
English DNA native antibody assay (procedure), Measurement of native deoxyribonucleic acid (DNA) antibody, Deoxyribonucleic acid native antibody assay, dsDNA binding autoantibody level (procedure), DNA native antibody assay, dsDNA binding autoantibody level, Deoxyribonucleic acid native antibody assay (procedure), Antibody to double stranded deoxyribonucleic acid measurement, Antibody to double stranded DNA measurement (procedure), Antibody to double stranded deoxyribonucleic acid measurement (procedure), Antibody to double stranded DNA measurement
Spanish determinación de anticuerpos anti - ADN nativo (procedimiento), medición de anticuerpos anti - ADN bicatenario (procedimiento), medición de anticuerpos anti - ADN bicatenario, medición de anticuerpos anti-ADN bicatenario (procedimiento), medición de anticuerpos anti-ADN bicatenario, medición de anticuerpos anti-ácido desoxirribonucleico (ADN) nativo, determinación de anticuerpos anti - DNA nativo, determinación de anticuerpos anti - ADN nativo, determinación de anticuerpos anti-ácido desoxirribonucleico (ADN) nativo, determinación de anticuerpos anti-ácido desoxirribonucleico (ADN) nativo (procedimiento)

Ontology: Double stranded anti DNA antibody (C0312612)

Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
SnomedCT 76731000
LNC LP38937-6, LP37936-9, MTHU010623, MTHU002322
English Double stranded anti DNA antibody, Native deoxyribonucleic acid (DNA) antibody, antibodies dna double stranded, dna ab ds, dsdna ab, antibodies dsdna, antibody dna double strand, dna double strand ab, Double stranded anti-deoxyribonucleic acid antibody (substance), Double stranded anti-deoxyribonucleic acid antibody, Double stranded anti DNA antibody (substance), little d little s DNA (Crithidia lucilia) Ab, DNA double strand Ab, ds deoxyribonucleic acid Antibody, deoxyribonucleic acid double strand Antibody, Anti Crithidia antibody, Double-stranded DNA antibody
Spanish anticuerpo anti - ADN de doble hebra, anticuerpo anti-ADN bicatenario, anticuerpo anti-ácido desoxirribonucleico de cadena doble, anticuerpo anti-ácido desoxirribonucleico bicatenario (sustancia), anticuerpo anti - ADN de doble hebra (sustancia), anticuerpo anti-ácido desoxirribonucleico bicatenario, anticuerpo anti Crithidia