Mixed Connective Tissue Disease

Aka: Mixed Connective Tissue Disease, Sharp Syndrome, MCTD Syndrome

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II. Definitions

  1. Mixed Connective Tissue Disease (MCTD)
    1. Condition with combined features of Systemic Lupus Erythematosus, Myositis and Scleroderma

III. Findings: Presentation

  1. Raynaud Phenomenon
  2. Pulmonary Hypertension
  3. Arthritis
  4. Myositis

IV. Labs

  1. Screening
    1. ANA Titer
  2. Confirmation
    1. Anti-ribonucleoprotein Antibody (Anti-RNP)
      1. Test Sensitivity for MCTD: 71-100%
      2. Test Specificity for MCTD: 84-100%

V. References

  1. Ali (2018) Am Fam Physician 98(3): 164-70 [PubMed]

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