Anti-Topoisomerase I Antibody

Aka: Anti-Topoisomerase I Antibody, Anti-Topoisomerase1 Antibody, Anti-Scl-70 Antibody, Anti-Topoisomerase I, Topoisomerase 1 Antibody, Anti-DNA-Topoisomerase I, Anti-Scl-70

advertisement

II. Causes: Negative

  1. Normal

III. Causes: Positive (Percentage refers to sensitivity)

  1. Scleroderma (20-30% sensitivity)
    1. Anti-Scl-70 is highly specific for Scleroderma
    2. Implies a poor prognosis
  2. Associated with renal involvement

IV. References

  1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
  2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
  3. Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed]
  4. Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed]

Images: Related links to external sites (from Bing)

These images are a random sampling from a Bing search on the term "Anti-Topoisomerase I Antibody." Click on the image (or right click) to open the source website in a new browser window. Search Bing for all related images

Related Studies

Related Topics in Pathology and Laboratory Medicine

advertisement