II. Causes: Negative
- Normal
III. Causes: Positive (Percentage refers to sensitivity)
-
Scleroderma (20-30% sensitivity)
- Anti-Scl-70 is highly specific for Scleroderma
- Implies a poor prognosis
- Associated with renal involvement
IV. References
- Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
- Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
- Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed]
- Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed]
Images: Related links to external sites (from Bing)
Related Studies
| Concepts | Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129) |
| English | Anti-Scl70 Antibody |
Ontology: Topoisomerase-1 antibody (C0700437)
| Concepts | Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129) |
| SnomedCT | 259928007 |
| LNC | LP39721-3, MTHU007651 |
| English | Scl-70 - Scleroderma-70 ab, SCL-70 extractable nuclear Antibody, SCL-70 extractable nuclear Ab, Scl-70 - Scleroderma-70 antibody, Topoisomerase-1 antibody, Topoisomerase-1 antibody (substance) |
| Spanish | anticuerpo antitopoisomerasa-1 (sustancia), anticuerpo antitopoisomerasa-1 |
