II. Causes: Negative

  1. Normal

III. Causes: Positive (Percentage refers to sensitivity)

  1. Scleroderma (20-30% sensitivity)
    1. Anti-Scl-70 is highly specific for Scleroderma
    2. Implies a poor prognosis
  2. Associated with renal involvement

IV. References

  1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
  2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
  3. Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed]
  4. Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed]

Images: Related links to external sites (from Bing)

Related Studies (from Trip Database) Open in New Window

Ontology: Anti-Scl70 Antibody (C0236513)

Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
English Anti-Scl70 Antibody

Ontology: Topoisomerase-1 antibody (C0700437)

Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
SnomedCT 259928007
LNC LP39721-3, MTHU007651
English Scl-70 - Scleroderma-70 ab, SCL-70 extractable nuclear Antibody, SCL-70 extractable nuclear Ab, Scl-70 - Scleroderma-70 antibody, Topoisomerase-1 antibody, Topoisomerase-1 antibody (substance)
Spanish anticuerpo antitopoisomerasa-1 (sustancia), anticuerpo antitopoisomerasa-1