II. Mechanism

  1. IgM, IgG, or IgA binding to cell-membrane constituents
  2. Measured by enzyme-linked immunosorbent assay

III. Indications: APL testing

  1. Connective Tissue Disease with clotting disorder
  2. Recurrent thrombosis without obvious cause
    1. See Hypercoagulability

IV. Types: Antiphospholipid Antibodies

  1. Anticardiolipin Antibody (ACA)
  2. Lupus Anticoagulant
    1. Prolongs Partial Thromboplastin Time (PTT)
    2. Prolongs Russell viper venom time
  3. VDRL False Positive

V. Causes: APL elevations (>3 SD)

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