II. Mechanism
- IgM, IgG, or IgA binding to cell-membrane constituents
- Measured by enzyme-linked immunosorbent assay
III. Indications: APL testing
- Connective Tissue Disease with clotting disorder
- Recurrent thrombosis without obvious cause
IV. Types: Antiphospholipid Antibodies
- Anticardiolipin Antibody (ACA)
-
Lupus Anticoagulant
- Prolongs Partial Thromboplastin Time (PTT)
- Prolongs Russell viper venom time
- VDRL False Positive
V. Causes: APL elevations (>3 SD)
Images: Related links to external sites (from Bing)
Related Studies
| Definition (MSH) | Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals. |
| Concepts | Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129) |
| MSH | D017152 |
| SnomedCT | 259916004 |
| LNC | LP21197-6, MTHU008546 |
| English | Antiphospholipid Antibody, Antiphospholipid Antibodies, Antibodies, Antiphospholipid, Antibody, Antiphospholipid, Antiphospholipid antibody, aPL - Anti-phospholip antibody, Anti-phospholipid autoantibody, APLA - Anti-phospholipid ab, Antibodies, Antiphospholipid [Chemical/Ingredient], anti phospholipid antibodies, antibody antiphospholipids, antiphospholipid antibody, phospholipid antibody, antibodies phospholipid, antibodies antiphospholipid, anti-phospholipid antibody, antibody antiphospholipid, antiphospholipid antibodies, Phospholipid Antibody, Phospholipid Ab, Anti-phospholipid antibody, Phospholipid antibody, aPL - Anti-phospholipid antibody, APLA - Anti-phospholipid antibody, Phospholipid autoantibody, Anti-phospholipid autoantibody (substance), Anti-phospholipid antibody (substance) |
| Swedish | Antifosfolipidantikroppar |
| Finnish | Fosfolipidivasta-aineet |
| Italian | Anticorpo antifosfolipidico, Anticorpi antifosfolipidici |
| Russian | ANTIFOSFOLIPIDNYE ANTITELA, ANTITELA ANTIFOSFOLIPIDNYE, АНТИТЕЛА АНТИФОСФОЛИПИДНЫЕ, АНТИФОСФОЛИПИДНЫЕ АНТИТЕЛА |
| French | Anticorps anti-phospholipides, Anticorps antiphospholipides |
| Croatian | ANTITIJELA, ANTIFOSFOLIPIDNA |
| Polish | Przeciwciała antyfosfolipidowe, Przeciwciała przeciwfosfolipidowe |
| Japanese | 抗体-抗りん脂質, 抗リン脂質抗体, 抗りん脂質抗体, 抗体-抗リン脂質, 抗体-抗燐脂質, 抗燐脂質抗体 |
| Czech | antifosfolipidové protilátky, protilátky antifosfolipidové |
| Spanish | Anticuerpos contra Fosfolípidos, anticuerpo antifosfolipídico (sustancia), anticuerpo antifosfolipídico, Anticuerpos Anti Fosfolípidos, Anticuerpos Antifosfolípidos |
| German | Antikörper, Antiphospholipid-, Antiphospholipidantikörper |
| Portuguese | Anticorpos Antifosfolipídeos, Anticorpos Antifosfolipídicos |
Ontology: Antibodies, Anticardiolipin (C0162596)
| Definition (NCI) | An autoantibody that reacts with cardiolipin. Different immunoglobulin subclasses and isotypes are associated with different diseases and conditions. Some anticardiolipin antibodies prolong phospholipid dependent clotting while others are associated with spontaneous abortion. |
| Definition (MSH) | Antiphospholipid antibodies found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. The antibodies are detected by solid-phase IMMUNOASSAY employing the purified phospholipid antigen CARDIOLIPIN. |
| Concepts | Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129) |
| MSH | D017153 |
| SnomedCT | 45396006, 57380001 |
| LNC | LP21333-7, MTHU014089 |
| English | Anticardiolipin Antibody, Anticardiolipin Antibodies, Antibodies, Anticardiolipin, Antibody, Anticardiolipin, ACLA - Anti-cardiolipin antib, Anti cardiolipin antibody, Antibodies, Anticardiolipin [Chemical/Ingredient], anti antibody cardiolipin, anti-cardiolipin antibody, anticardiolipin antibodies, anticardiolipin antibody, anti antibodies cardiolipins, cardiolipin antibody, anti antibodies cardiolipin, antibody anticardiolipin, abs cardiolipin, anti cardiolipin antibodies, anti cardiolipin antibody, anti cardiolipins antibody, antibody cardiolipin, cardiolipin ab, Anticardiolipin antibody, Anticardiolipin antibody (substance), Cardiolipin Antibody, Cardiolipin Ab, Anti-Cardiolipin Antibody, ACA - Cardiolipin antibody, Anti-cardiolipin antibody, Cardiolipin antibody, ACLA - Anti-cardiolipin antibody, Cardiolipin antibody (substance), Anti cardiolipin antibody (substance), Anticardiolipin antibody -RETIRED- |
| Swedish | Antikardiolipinantikroppar |
| Finnish | Kardiolipiinivasta-aineet |
| Italian | Anticorpo anticardiolipinico, Anticorpi anticardiolipinici |
| Russian | ANTITELA ANTIKARDIOLIPIDNYE, ANTIKARDIOLIPIDNYE ANTITELA, АНТИКАРДИОЛИПИДНЫЕ АНТИТЕЛА, АНТИТЕЛА АНТИКАРДИОЛИПИДНЫЕ |
| Japanese | 抗カルジオリピン抗体, 抗体-抗カルジオリピン |
| French | Anticorps anti-cardiolipines, Anticorps anticardiolipines |
| Polish | Przeciwciała przeciwkardiolipinowe, Przeciwciała antykardiolipinowe |
| Croatian | ANTIKARDIOLIPINSKA PROTUTIJELA, ANTITIJELA, ANTIKARDIOLIPINSKA, ANTIKARDIOLIPINSKA ANTITIJELA |
| Czech | antikardiolipinové protilátky, protilátky antikardiolipinové, protilátky proti kardiolipinu |
| Spanish | anticuerpo anticardiolipina - RETIRADO - (concepto no activo), anticuerpo anticardiolipina - RETIRADO -, anticuerpo anticardiolipina (sustancia), anticuerpo anticardiolipina, Anticuerpos Anticardiolipina |
| German | Antikardiolipinantikörper, Antikörper, Antikardiolipin- |
| Portuguese | Anticorpos Anticardiolipina |
Ontology: Antiphospholipid antibodies measurement (C0201534)
| Definition (NCI) | The determination of the amount of antiphospholipid antibodies present in a sample. |
| Definition (NCI_CDISC) | A measurement of the antiphospholipid antibodies in a biological specimen. |
| Concepts | Laboratory Procedure (T059) |
| SnomedCT | 82886000 |
| Italian | Anticorpi antifosfolipidi |
| Japanese | 抗リン脂質抗体, ｺｳﾘﾝｼｼﾂｺｳﾀｲ, ＡＰＡ, APA |
| Czech | Antifosfolipidové protilátky, APA |
| English | antiphospholipid antibodies test, APA, Antiphospholipid Antibody Measurement, Antiphospholipid Antibodies, APLAB, Antiphospholipid antibodies, Antiphospholipid antibodies measurement, Antiphospholipid antibody measurement, Antiphospholipid antibody measurement (procedure) |
| Spanish | APA, medición de anticuerpos antifosfolipídicos (procedimiento), medición de anticuerpos antifosfolipídicos, Anticuerpos antifosfolípido |
| Portuguese | APA, Anticorpos antifosfolípido |
| German | APA, Phospholipidantikoerper |
| French | Acide amino-pénicillanique (APA), Anticorps anti-phospholipides |
| Dutch | APA, antifosfolipiden-antistoffen |
| Hungarian | APA, Antifoszfolipid antitestek |
Ontology: Anticardiolipin antibody measurement (C0201535)
| Concepts | Laboratory Procedure (T059) |
| SnomedCT | 389545003, 390277008, 65946008 |
| English | Anticardiolipin antibody measurement, Cardiolipin antibody, Antibodies anticardiolipin, Anticardiolipin antibodies, Antibodies cardiolipin, Cardiolipin antibodies, anticardiolipin antibody level test, Anti-cardiolipin antibody level, Anti-cardiolipin antibody level (procedure), Anti-cardiolipin level, Anticardiolipin antibody measurement (procedure) |
| Italian | Anticorpo anticardiolipina, Anticorpi anticardiolipina, Anticorpo anti-cardiolipina |
| Dutch | antistoffen anticardiolipine, cardiolipineantistoffen, antistoffen cardiolipine, anticardiolipineantistoffen, cardiolipineantistof |
| German | Anticardiolipin-Antikoerper, Antikoerper Anticardiolipin, Antikoerper Cardiolipin, Cardiolipin-Antikoerper |
| Portuguese | Anticorpos anticardiolipina, Anticorpos cardiolipina, Anticorpo anticardiolipina |
| Japanese | カルジオリピン抗体, 抗カルジオリピン抗体, ｶﾙｼﾞｵﾘﾋﾟﾝｺｳﾀｲ, ｺｳｶﾙｼﾞｵﾘﾋﾟﾝｺｳﾀｲ |
| Czech | Antikardiolipinové protilátky, Protilátky proti kardiolipinu |
| Hungarian | Kardiolipin elleni antitest, Kardiolipin elleni antitestek, Kardiolipin antitestek |
| Spanish | medición de anticuerpos anticardiolipínicos (procedimiento), medición de anticuerpos anticardiolipínicos, Anticuerpos anticardiolipina |
| French | Anticorps anti-cardiolipine |
