II. Mechanism

  1. IgM, IgG, or IgA binding to cell-membrane constituents
  2. Measured by enzyme-linked immunosorbent assay

III. Indications: APL testing

  1. Connective Tissue Disease with clotting disorder
  2. Recurrent thrombosis without obvious cause
    1. See Hypercoagulability

IV. Types: Antiphospholipid Antibodies

  1. Anticardiolipin Antibody (ACA)
  2. Lupus Anticoagulant
    1. Prolongs Partial Thromboplastin Time (PTT)
    2. Prolongs Russell viper venom time
  3. VDRL False Positive

V. Causes: APL elevations (>3 SD)

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Related Studies

Ontology: Antiphospholipid Antibodies (C0162595)

Definition (MSH) Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals.
Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
MSH D017152
SnomedCT 259916004
LNC LP21197-6, MTHU008546
English Antiphospholipid Antibody, Antiphospholipid Antibodies, Antibodies, Antiphospholipid, Antibody, Antiphospholipid, Antiphospholipid antibody, aPL - Anti-phospholip antibody, Anti-phospholipid autoantibody, APLA - Anti-phospholipid ab, Antibodies, Antiphospholipid [Chemical/Ingredient], anti phospholipid antibodies, antibody antiphospholipids, antiphospholipid antibody, phospholipid antibody, antibodies phospholipid, antibodies antiphospholipid, anti-phospholipid antibody, antibody antiphospholipid, antiphospholipid antibodies, Phospholipid Antibody, Phospholipid Ab, Anti-phospholipid antibody, Phospholipid antibody, aPL - Anti-phospholipid antibody, APLA - Anti-phospholipid antibody, Phospholipid autoantibody, Anti-phospholipid autoantibody (substance), Anti-phospholipid antibody (substance)
Swedish Antifosfolipidantikroppar
Finnish Fosfolipidivasta-aineet
Italian Anticorpo antifosfolipidico, Anticorpi antifosfolipidici
French Anticorps anti-phospholipides, Anticorps antiphospholipides
Polish Przeciwciała antyfosfolipidowe, Przeciwciała przeciwfosfolipidowe
Japanese 抗体-抗りん脂質, 抗リン脂質抗体, 抗りん脂質抗体, 抗体-抗リン脂質, 抗体-抗燐脂質, 抗燐脂質抗体
Czech antifosfolipidové protilátky, protilátky antifosfolipidové
Spanish Anticuerpos contra Fosfolípidos, anticuerpo antifosfolipídico (sustancia), anticuerpo antifosfolipídico, Anticuerpos Anti Fosfolípidos, Anticuerpos Antifosfolípidos
German Antikörper, Antiphospholipid-, Antiphospholipidantikörper
Portuguese Anticorpos Antifosfolipídeos, Anticorpos Antifosfolipídicos

Ontology: Antibodies, Anticardiolipin (C0162596)

Definition (NCI) An autoantibody that reacts with cardiolipin. Different immunoglobulin subclasses and isotypes are associated with different diseases and conditions. Some anticardiolipin antibodies prolong phospholipid dependent clotting while others are associated with spontaneous abortion.
Definition (MSH) Antiphospholipid antibodies found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. The antibodies are detected by solid-phase IMMUNOASSAY employing the purified phospholipid antigen CARDIOLIPIN.
Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
MSH D017153
SnomedCT 45396006, 57380001
LNC LP21333-7, MTHU014089
English Anticardiolipin Antibody, Anticardiolipin Antibodies, Antibodies, Anticardiolipin, Antibody, Anticardiolipin, ACLA - Anti-cardiolipin antib, Anti cardiolipin antibody, Antibodies, Anticardiolipin [Chemical/Ingredient], anti antibody cardiolipin, anti-cardiolipin antibody, anticardiolipin antibodies, anticardiolipin antibody, anti antibodies cardiolipins, cardiolipin antibody, anti antibodies cardiolipin, antibody anticardiolipin, abs cardiolipin, anti cardiolipin antibodies, anti cardiolipin antibody, anti cardiolipins antibody, antibody cardiolipin, cardiolipin ab, Anticardiolipin antibody, Anticardiolipin antibody (substance), Cardiolipin Antibody, Cardiolipin Ab, Anti-Cardiolipin Antibody, ACA - Cardiolipin antibody, Anti-cardiolipin antibody, Cardiolipin antibody, ACLA - Anti-cardiolipin antibody, Cardiolipin antibody (substance), Anti cardiolipin antibody (substance), Anticardiolipin antibody -RETIRED-
Swedish Antikardiolipinantikroppar
Finnish Kardiolipiinivasta-aineet
Italian Anticorpo anticardiolipinico, Anticorpi anticardiolipinici
Japanese 抗カルジオリピン抗体, 抗体-抗カルジオリピン
French Anticorps anti-cardiolipines, Anticorps anticardiolipines
Polish Przeciwciała przeciwkardiolipinowe, Przeciwciała antykardiolipinowe
Czech antikardiolipinové protilátky, protilátky antikardiolipinové, protilátky proti kardiolipinu
Spanish anticuerpo anticardiolipina - RETIRADO - (concepto no activo), anticuerpo anticardiolipina - RETIRADO -, anticuerpo anticardiolipina (sustancia), anticuerpo anticardiolipina, Anticuerpos Anticardiolipina
German Antikardiolipinantikörper, Antikörper, Antikardiolipin-
Portuguese Anticorpos Anticardiolipina

Ontology: Antiphospholipid antibodies measurement (C0201534)

Definition (NCI) The determination of the amount of antiphospholipid antibodies present in a sample.
Definition (NCI_CDISC) A measurement of the antiphospholipid antibodies in a biological specimen.
Concepts Laboratory Procedure (T059)
SnomedCT 82886000
Italian Anticorpi antifosfolipidi
Japanese 抗リン脂質抗体, コウリンシシツコウタイ, APA, APA
Czech Antifosfolipidové protilátky, APA
English antiphospholipid antibodies test, APA, Antiphospholipid Antibody Measurement, Antiphospholipid Antibodies, APLAB, Antiphospholipid antibodies, Antiphospholipid antibodies measurement, Antiphospholipid antibody measurement, Antiphospholipid antibody measurement (procedure)
Spanish APA, medición de anticuerpos antifosfolipídicos (procedimiento), medición de anticuerpos antifosfolipídicos, Anticuerpos antifosfolípido
Portuguese APA, Anticorpos antifosfolípido
German APA, Phospholipidantikoerper
French Acide amino-pénicillanique (APA), Anticorps anti-phospholipides
Dutch APA, antifosfolipiden-antistoffen
Hungarian APA, Antifoszfolipid antitestek

Ontology: Anticardiolipin antibody measurement (C0201535)

Concepts Laboratory Procedure (T059)
SnomedCT 389545003, 390277008, 65946008
English Anticardiolipin antibody measurement, Cardiolipin antibody, Antibodies anticardiolipin, Anticardiolipin antibodies, Antibodies cardiolipin, Cardiolipin antibodies, anticardiolipin antibody level test, Anti-cardiolipin antibody level, Anti-cardiolipin antibody level (procedure), Anti-cardiolipin level, Anticardiolipin antibody measurement (procedure)
Italian Anticorpo anticardiolipina, Anticorpi anticardiolipina, Anticorpo anti-cardiolipina
Dutch antistoffen anticardiolipine, cardiolipineantistoffen, antistoffen cardiolipine, anticardiolipineantistoffen, cardiolipineantistof
German Anticardiolipin-Antikoerper, Antikoerper Anticardiolipin, Antikoerper Cardiolipin, Cardiolipin-Antikoerper
Portuguese Anticorpos anticardiolipina, Anticorpos cardiolipina, Anticorpo anticardiolipina
Japanese カルジオリピン抗体, 抗カルジオリピン抗体, カルジオリピンコウタイ, コウカルジオリピンコウタイ
Czech Antikardiolipinové protilátky, Protilátky proti kardiolipinu
Hungarian Kardiolipin elleni antitest, Kardiolipin elleni antitestek, Kardiolipin antitestek
Spanish medición de anticuerpos anticardiolipínicos (procedimiento), medición de anticuerpos anticardiolipínicos, Anticuerpos anticardiolipina
French Anticorps anti-cardiolipine