Anticyclic Citrullinated Peptide Antibody

Aka: Anticyclic Citrullinated Peptide Antibody, Anti-cyclic Citrullinated Peptide Antibody

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II. Indications

  1. Rheumatoid Arthritis Diagnosis confirmation
    1. Rheumatoid Factor or Antinuclear Antibody positive
    2. May also predict prognosis and erosive disease likelihood
    3. Does not correlate to therapy response (not used for monitoring)

III. Mechanism

  1. Enzyme-linked Immunosorbent Assay (ELISA)

IV. Efficacy: Rheumatoid Arthritis Diagnosis

  1. Test Sensitivity: 67%
  2. Test Specificity: 95%
  3. Positive Likelihood Ratio (LR+): 12.46
  4. Negative Likelihood Ratio (LR-): 0.36

V. References

  1. Ali (2018) Am Fam Physician 98(3): 164-70 [PubMed]
  2. Barra (2011) Rheumatology 50(2): 311-6 [PubMed]
  3. Nishimura (2007) Ann Intern Med 146(11): &97-808 [PubMed]

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Ontology: Anti-cyclic citrullinated peptide antibody (C2210597)

Concepts Laboratory Procedure (T059)
English anti-cyclic citrullinated peptide antibody, Anti-cyclic citrullinated peptide antibody, serum cyclic citrullinated peptide antibody test, serum cyclic citrullinated peptide IgG antibody (lab test), serum cyclic citrullinated peptide IgG antibody
Spanish Anticuerpo anti-péptido citrulinado cíclico
Portuguese Anticorpo anti-péptido cíclico citrulinado
Dutch anticyclisch gecitrullineerd peptide-antistof
Italian Anticorpo anti peptide citrullinato ciclico
French Anticorps anti-peptide cyclique citrulliné
German Cyclische Citrullin Peptid-Antikoerper
Czech Protilátka anticyklického citrulinového peptidu
Japanese ｺｳｻｲｸﾘｯｸｼﾄﾙﾘﾝｶﾍﾟﾌﾟﾁﾄﾞｺｳﾀｲ, 抗サイクリックシトルリン化ペプチド抗体
Hungarian Anti-ciklikus citrullinált peptid antitest
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pathology and Laboratory Medicine

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