II. Indications (used more as a research tool currently)
- Monitor peri-menopausal and postmenopausal bone loss
- Monitor treatment outcomes
III. Labs: Bone formation (Serum markers)
- Alkaline Phosphatase (total)
- Alkaline Phosphatase (skeletal isoenzymes)
- Procollagen-I Extension peptide
- Osteocalcin
IV. Labs: Bone resorption (most are urine markers)
- Urine Calcium
- Urine hydroxyproline
- Serum type I Collagen breakdown product (serum CTX)
- Collagen cross-link fragments (first to be hydrolyzed)