Urine Calcium

Aka: Urine Calcium, Hypercalciuria, Hypocalciuria, Urine Calcium to Creatinine Ratio, 24 hour Urine Calcium

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II. Interpretation: Normal

  1. Urine Calcium/24 hours
    1. Women: Urine Calcium 20 to 250 mg per 24 hours
    2. Men: Urine Calcium 25 to 300 mg per 24 hours
  2. Urine Calcium to Creatine ratio (24 hour collection)
    1. Adults: 0.01 to 0.22 mg Urine Calcium/mg Urine Creatinine

III. Interpretation: Increased

  1. Associated Hypercalcemia
    1. Primary Hyperparathyroidism
    2. Hypervitaminosis D
    3. Sarcoidosis
    4. Bone metastases
    5. Multiple Myeloma
    6. Corticosteroids
    7. Prolonged immobilization
    8. Paget's Disease
  2. No Associated Hypercalcemia
    1. Increased Calcium intake
    2. Idiopathic Hypercalciuria
    3. Renal tubule acidosis
    4. X-Linked Hypercalciuria (Dent's Disease)
  3. Hypocalcemia
    1. Calcium-sensing receptor activating mutation

IV. Interpretation: Decreased (<0.01 Urine Calcium to Creatinine Ratio or <20-25 mg Urine Calcium/24 hours)

  1. Hypoparathyroidism
  2. Pseudo-Hypoparathyroidism
  3. Vitamin D Deficiency
  4. Low Calcium diet
  5. Familial Hypocalciuric Hypercalcemia
  6. Renal Osteodystrophy
  7. Medications
    1. Thiazide Diuretics
    2. Oral Contraceptives

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