II. Epidemiology
- Not banned by IOC or NCAA
- Not detected by testing
III. Physiology
IV. Sources
V. Efficacy
- Mixed results from randomized trials
- Studies find strength and mass increase (men and women)
VI. Adverse Effects
- Weight gain (short-term, <1 week following intake)
- Probably safe
-
Renal Failure in patient with Nephrotic Syndrome
- No renal effects in later study of healthy men
- Anecdotal reports of assorted conditions reported
- Adverse effects beyond 3 months has not been studied
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Related Studies
| Definition (NCI) | An endogenous amino acid derivative produced by vertebrate animals and occurring primarily in muscle cells. Creatine is important for energy storage; it is phosphorylated to creatine phosphate, which serves as a phosphate donor in the conversion of ADP to ATP and supplies energy necessary for muscle contraction. Dietary supplementation with creatine may improve muscle wasting associated with cancer and other chronic diseases. |
| Definition (NCI_NCI-GLOSS) | A substance that is made by the body and used to store energy. It is being studied in the treatment of weight loss related to cancer. It is derived from the amino acid arginine. |
| Definition (MSH) | An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine. |
| Definition (CSP) | amino acid that is synthesized in vertebrate tissues; in muscle tissue, creatine generally occurs as phosphocreatine, an important storage form of high energy phosphate; excreted as creatinine. |
| Definition (PDQ) | An endogenous amino acid derivative produced by vertebrate animals and occurring primarily in muscle cells. Creatine is important for energy storage; it is phosphorylated to creatine phosphate, which serves as a phosphate donor in the conversion of ADP to ATP and supplies energy necessary for muscle contraction. Dietary supplementation with creatine may improve muscle wasting associated with cancer and other chronic diseases. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=361777&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=361777&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C37937" NCI Thesaurus) |
| Concepts | Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116) |
| MSH | D003401 |
| SnomedCT | 14804005 |
| LNC | LP15509-0, LP32032-2, MTHU005167 |
| English | Creatine, Glycine, N-(aminoiminomethyl)-N-methyl-, Creatine [Chemical/Ingredient], creatines, CREATINE, creatine, Creatine (substance) |
| Swedish | Kreatin |
| Czech | kreatin |
| Finnish | Kreatiini |
| Russian | KREATIN, КРЕАТИН |
| Croatian | KREATIN |
| Polish | Kreatyna |
| Spanish | creatina (sustancia), creatina, Creatina |
| French | Créatine |
| German | Creatin, Kreatin |
| Italian | Creatina |
| Portuguese | Creatina |
