II. Normal

  1. Adults
    1. Men: 0.8 to 1.3 mg/dl
    2. Women: 0.6 to 1.0 mg/dl
  2. Children (under age 20 years)
    1. Boys: 0.35 + (age in years)/40
    2. Girls: 0.35 + (age in years)/55

III. Protocol: New

  1. Standardized Creatinine (S-Creatinine)
    1. New, more accurate technique for measuring Serum Creatinine
    2. Not as affected by interfering substances
    3. Expect a drop in Serum Creatinine of 20% when switching to S-Creatinine measurement

IV. Pathophysiology

  1. Increases by 1.0-1.5 mg/dl/day if no Renal Function
  2. Often unchanged until 25-50% of Renal Function lost
  3. Doubled Serum Creatinine implies 50% Renal Function

V. Increased

  1. Renal Insufficiency
  2. Decreased renal perfusion
  3. Urinary Tract Infections
  4. Skeletal muscle Trauma or Rhabdomyolysis
  5. Ketonemia
  6. Diabetic Ketoacidosis
  7. Creatine Supplementation >15-20 grams per day
    1. May increase Serum Creatinine over 2.0
  8. Medications (Inhibit tubular secretion of Creatinine)
    1. Aminoglycosides
    2. Cephalosporins
      1. Cefoxitin
      2. Cephalothin
    3. Hydantoin
    4. Diuretics
    5. Methyldopa
    6. Cimetidine
    7. Trimethoprim

VI. Decreased

  1. Decreased Muscle mass
  2. Pregnancy

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Related Studies

Ontology: Creatinine (C0010294)

Definition (NCI) The breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function.
Definition (NCI_NCI-GLOSS) A compound that is excreted from the body in urine. Creatinine levels are measured to monitor kidney function.
Definition (CSP) nitrogen compound in muscle, blood and urine that is the end product of creatine metabolism.
Concepts Biologically Active Substance (T123) , Organic Chemical (T109)
MSH D003404
SnomedCT 15373003
LNC LP14355-9, LP32035-5, MTHU002337
English Creatinine, 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-, Creatinine [Chemical/Ingredient], creatinine, creatinines, CREATININE, Creatinine (substance)
Swedish Kreatinin
Czech kreatinin
Finnish Kreatiniini
Japanese クレアチニン, メチルグアニジノ酢酸, メチルグリコシアミジン
Polish Kreatynina
Spanish creatinina (sustancia), creatinina, Creatinina
French Créatinine
German Creatinin, Kreatinin
Italian Creatinina
Portuguese Creatinina

Ontology: Creatinine measurement, serum (procedure) (C0201976)

Definition (NCI) A quantitative measurement of the amount of creatinine present in a sample of serum.
Concepts Laboratory Procedure (T059)
SnomedCT 166713004, 144007006, 166718008, 113075003
LNC LP145994-2
Dutch serum creatinine
French Créatinine sérique
German Kreatinin im Serum
Italian Creatinina sierica
Portuguese Creatinina sérica
Spanish Creatinina en suero, determinación sérica de creatinina, SAI (procedimiento), determinación sérica de creatinina, SAI, medición de creatinina en suero (procedimiento), medición de creatinina en suero
Japanese 血清クレアチニン, ケッセイクレアチニン
English Serum Creatinine Measurement, Creatinine measurement, serum (procedure), serum creatinine level, serum creatinine measurement (lab test), serum creatinine measurement, creatinine procedure serum, creatinine serum test, creatinine serum, serum creatinine tests, serum creatinine, serum creatinine test, Creatinine.serum, Serum creatinine (& level) (procedure), Creatinine - serum, Serum creatinine NOS (procedure), Serum creatinine NOS, Serum creatinine (& level), Serum Creatinine Test, Creatinine measurement, serum, Serum creatinine
Czech Sérový kreatinin
Hungarian Szérum kreatinin