II. Indications
- Decomensated Congestive Heart Failure
III. Mechanism
- Recombinant Human Brain Natriuretic Peptide
- Results in venous and arterial vasodilation
IV. Dosing
- Bolus: 2 mcg/kg IV bolus
- Maintenance: 0.01 mcg/kg/min for 24-48 hours
V. Efficacy
- Improves CHF symptoms
- Increases mortality within first 30 days
- Sackner-Bernstein (2005) JAMA 293:1900-5 [PubMed]
VI. Cost
- Typical course is 2 vials at $530 per vial
VII. Monitoring
- Blood Pressure during administration (Hypotension risk)
- Serum Creatinine