II. Indications

III. Mechanism

  1. Recombinant Human Brain Natriuretic Peptide
  2. Results in venous and arterial vasodilation

IV. Dosing

  1. Bolus: 2 mcg/kg IV bolus
  2. Maintenance: 0.01 mcg/kg/min for 24-48 hours

V. Efficacy

  1. Improves CHF symptoms
  2. Increases mortality within first 30 days
  3. Sackner-Bernstein (2005) JAMA 293:1900-5 [PubMed]

VI. Cost

  1. Typical course is 2 vials at $530 per vial

VII. Monitoring

  1. Blood Pressure during administration (Hypotension risk)
  2. Serum Creatinine

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