III. Mechanism

  1. Aryloxypropanolamine derivative
  2. Nonselective Beta Blocker (Beta-1 and Beta-2 Adrenergic Blockade)
  3. Intrinsic Sympathomimetic activity (partial beta Agonist), similar to Acebutolol
  4. Also blocks Serotonin (5-HT) 1A receptors, increasing available CNS Serotonin with possible Antidepressant effects

IV. Dosing

  1. Start: 5 mg orally twice daily
  2. Target: 5 to 15 mg orally twice daily
  3. Maximum: 60 mg/day

V. Adverse Effects

VI. Safety

  1. Pregnancy Category B
  2. Unknown safety in Lactation

VIII. References

  1. (2019) Presc Lett, Resource #350503, Comparison of Oral Beta Blockers
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 66-7
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Related Studies

Cost: Medications

pindolol (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
PINDOLOL 10 MG TABLET Generic $0.83 each
PINDOLOL 5 MG TABLET Generic $0.80 each

Ontology: Pindolol (C0031937)

Definition (NCI) An aryloxypropanolamine derivative with antihypertensive property. Pindolol competitively binds to beta-adrenergic receptors, resulting in a decrease in beta-adrenergic activities, i.e., vasodilation, and negative chronotropic and inotropic effects. In addition, this agent blocks serotonin (5-HT) 1A receptors, thereby increasing the available serotonin in the brain. Increased serotonin levels augment the antidepressant action of selective serotonin reuptake inhibitors and monoamine oxidase inhibitors.
Definition (MSH) A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D010869
SnomedCT 18381001, 387102009
LNC LP16255-9, MTHU018207
English Pindolol, Prindolol, 2-Propanol, 1-(1H-indol-4-yloxy)-3-((1-methylethyl)amino)-, 1-(1H-Indol-4-yloxy)-3-((1-methylethyl)amino)-2-propanol, pindolol, pindolol (medication), PINDOLOL, Pindolol [Chemical/Ingredient], prindolol, Prinodolol, Pindolol (product), Pindolol (substance)
Swedish Pindolol
Czech pindolol
Finnish Pindololi
French Prindolol, Pindolol
Russian PRINDOLOL, PINDOLOL, ПИНДОЛОЛ, ПРИНДОЛОЛ
Japanese プリンドロール, ブロクリンL, ブロクリン, ヒシクロピン, コカセリン, カルビスケン, カルビスケンR, パスチロン, カシムテンR, ピンドロール
Italian Prindololo, Pindololo
Polish Pindolol
Spanish pindolol (producto), pindolol (sustancia), pindolol, prinodolol, Pindolol, Prindolol
German Pindolol, Prindolol
Portuguese Pindolol, Prindolol

Ontology: Visken (C0699962)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D010869
French Visken
English visken, Visken