Direct Acting Vasodilator

Aka: Direct Acting Vasodilator, Diazoxide, Hyperstat, Vasodilator Antihypertensive Drugs

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II. Mechanism

  1. Direct vasodilators relax vascular Smooth Muscle
  2. One mechanism of vasodilation is mediated by nitric oxide in the vascular endothelium

III. Medications: Direct Acting Vasodilators IV

  1. Hydralazine (Apresoline)
    1. Dose: 10-40 mg IV/IM q4-6h
  2. Hydralazine with Isosorbide Dinitrate 37.5/20 (BiDil)
    1. Dose: 1-2 tablets orally three times daily
    2. For Class III CHF patients (esp. African American)
    3. Very expensive: $400/month
    4. Generic Drugs separately are $60/month
  3. Diazoxide (Hyperstat)
    1. Dose: 1-3 mg/kg up to 150 mg IV q5-15 min
  4. Nitroprusside Sodium (Nipride)
  5. Minoxidil (Loniten)
  6. Fenoldopam (Corlopam)

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Related Studies

Cost: Medications

diazoxide (on 11/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
DIAZOXIDE 50 MG/ML ORAL SUSP Generic $7.19 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Pharmacology

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