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Definition (NCI)
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A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells.
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Definition (CSP)
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peripheral vasodilator that reduces blood pressure; diazoxide also has antidiuretic and hypoglycemic effects.
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Definition (MSH)
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A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
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Definition (PDQ)
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A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39290&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39290&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C428" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D003981
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| SnomedCT |
318642007, 325291008, 387328001, 58905004 |
| LNC |
LP14713-9, MTHU001807 |
| English |
Diazoxide, 2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide, 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-Dioxide, diazoxide, Diazoxide [cardiovascular use], Diazoxide [endocrine use], diazoxide (medication), Diazoxide [Chemical/Ingredient], diazoxides, Diazoxide [cardiovascular use] (product), Diazoxide [endocrine use] (product), Diazoxide (product), Diazoxide (substance), Diazoxide [cardiovascular use] (substance), Diazoxide [endocrine use] (substance), DIAZOXIDE |
| Swedish |
Diazoxid
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| Czech |
diazoxid
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| Finnish |
Diatsoksidi
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| Russian |
DIAZOKSID, ДИАЗОКСИД |
| Japanese |
ダイアゾキサイド, ジアゾキシド |
| Croatian |
DIAZOKSID
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| Polish |
Diazoksyd
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| Spanish |
diazóxido (uso cardiovascular), diazóxido [uso endocrino], diazóxido (uso cardiovascular) (producto), diazóxido [uso endocrino] (producto), diazóxido (producto), diazóxido (sustancia), diazóxido, Diazóxido |
| French |
Diazoxide
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| German |
Diazoxid
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| Italian |
Diazossido
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| Portuguese |
Diazóxido
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