II. Indications
III. Dosing: Hypertension
- Take on an empty Stomach
- Start 17 mg orally daily
- Start at 8.5 mg orally daily in the elderly or hepatic Impairment
- Titrate as needed, increasing by 8.5 mg/day weekly
- Maximum: 34 mg/day
IV. Mechanism
V. Adverse Effects
VI. Safety
- Pregnancy Category C
- Unknown Safety in Lactation
VII. Resources
VIII. References
- (2022) Presc Lett, Resource #381108, Comparison of Calcium Channel Blockers
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 70-1
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
nisoldipine (on 5/18/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
NISOLDIPINE ER 17 MG TABLET | Generic | $5.09 each |
Ontology: Nisoldipine (C0028116)
Definition (NCI) | A dihydropyridine calcium channel blocking agent. Nisoldipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) |
Definition (MSH) | A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D015737 |
SnomedCT | 108524004, 386861009 |
English | Nisoldipine, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester, nisoldipine (medication), nisoldipine, Nisoldipine [Chemical/Ingredient], NISOLDIPINE, Nisoldipine (product), Nisoldipine (substance), Nisoldipine SR |
Swedish | Nisoldipin |
Czech | nisoldipin |
Finnish | Nisoldipiini |
Russian | NIZOLDIPIN, НИЗОЛДИПИН |
Japanese | ニソルジピン |
Spanish | nisoldipino, nisoldipina, nisoldipino (producto), nisoldipino (sustancia), nisoldipina (producto), nisoldipina (sustancia), Nisoldipino |
Polish | Nisoldipina |
French | Nisoldipine |
German | Nisoldipin |
Italian | Nisoldipina |
Portuguese | Nisoldipino |
Ontology: Sular (C0723503)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
English | Sular, sular |