II. Indications
- Not typically used for Hypertension
- Diuretic Resistance in Edematous States
III. Dosing: Edema (CHF, renal disease)
- Take 30 minutes before Loop Diuretic
- Start: 2.5 mg daily (esp. if combined with Loop Diuretic)
- Target: 5 to 10 mg orally daily
- Maximum: 10 mg/day in CHF (20 mg/day in renal disease)
IV. Mechanism
V. Pharmacokinetics
- Onset of activity within 1 hour
- Duration >24 hours
VI. Adverse Effects
- See Thiazide Diuretic
- Monitor for Electrolyte disturbance (esp. when combined with Loop Diuretics)
- Hypovolemia with contraction alkalosis
- Hypokalemia
- Hyperuricemia
- Hyperglycemia
- Hyperlipidemia
- Hypercalcemia
VII. Safety
- Unknown Safety in Lactation
- Pregnancy Category B
- Pregnancy Category D if used for Pregnancy Induced Hypertension
VIII. Resources
IX. References
- (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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