II. Indications

  1. Chronic Angina Prophylaxis

III. Dosing

  1. Transdermal Nitroglycerin Patch
    1. Apply 1 patch for 12 to 14 hours per day to non-hairy skin
    2. Doses range from 0.1 to 0.8 mg per hour
    3. Allow for a nitrate free period for 10-14 hours per day

IV. Mechanism

V. Adverse Effects

VI. Safety

  1. Pregnancy Category C
  2. Unknown Safety in Lactation

VIII. References

  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 70-1
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Related Studies

Ontology: Nitroglycerin Transdermal Patch (C0699222)

Definition (NCI) A sustained release transdermal patch containing the organic nitrate nitroglycerin, with vasodilator and potential immunomodulating activities. Upon application to the skin, nitroglycerin is continuously released from the patch and absorbed. In turn, nitroglycerin is converted into nitric oxide (NO), which activates guanylyl cyclase, increasing cyclic guanosine monophosphate concentration thus resulting in smooth muscle relaxation. In addition, activation of NO-mediated signaling pathways may inhibit hypoxia-induced tumor cell invasiveness, chemoresistance, evasion of immune cell recognition and cancer cell progression. Particularly, reactivation of NO-mediated signaling appears to inhibit the increased tumor cell shedding of the major histocompatibility complex class I chain-related (MIC) molecules MICA and MICB as is seen in hypoxic tumor environments; MIC molecules play key roles in tumor cell immune surveillance through their interaction with the C-type lectin-like NKG2D receptor on natural killer, lymphokine-activated killer and effector T cells.
Concepts Clinical Drug (T200)
SnomedCT 356358008
English Nitroglycerin Transdermal Patch, GTN - Glyceryl trinitr patch, Nitroglycerin Patch, GTN Transdermal Patch, Glyceryl Trinitrate Transdermal Patch, GTN - Glyceryl trinitrate patch, Glyceryl trinitrate patch, Glyceryl trinitrate patch (product), Glyceryl trinitrate patch (substance)
Spanish trinitrato de glicerilo, parche (producto), trinitrato de glicerilo, parche

Ontology: Transdermal glyceryl trinitrate (C1445777)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
SnomedCT 412446007, 346462009
English Transdermal GTN, transdermal glyceryl trinitrate, Transdermal nitroglycerin (product), Transdermal glyceryl trinitrate, Transdermal glyceryl trinitrate (product), Transdermal glyceryl trinitrate (substance), Transdermal nitroglycerin
Spanish nitroglicerina transdérmica (producto), trinitrato de glicerilo transdérmico (producto), trinitrato de glicerilo transdérmico, nitroglicerina transdérmica