II. Indications
III. Dosing: Adults
- Oral (Hypertension or Edema)
- Start: 125-250 orally daily or divided twice daily
- Maximum: 500 mg orally twice daily
- Intravenous (Edema)
- IV Chlorothiazide is the only intravenous Thiazide Diuretic
- Dose: 0.5 to 1 mg IV daily to twice daily
IV. Pharmacokinetics
- Onset of activity <2 hours
- Duration: 6 to 12 hours
V. Mechanism
VI. Adverse Effects
VII. Safety
- Pregnancy Category C
- Pregnancy Category D if used for Pregnancy Induced Hypertension
- Considered Safe in Lactation
VIII. Resources
- Chlorothiazide (DailyMed)
IX. References
- (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Definition (NCI) | A short-acting, benzothiadiazinesulfonamide derivative and prototypical thiazide diuretic. Chlorothiazide is excreted unchanged by the kidneys. |
Definition (MSH) | A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) |
Definition (CSP) | thiazide diuretic used to treat hypertension. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D002740 |
SnomedCT | 372782002, 5786005 |
LNC | LP16071-0, MTHU008128 |
English | Chlorothiazide, 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide, chlorothiazide, chlorothiazide (medication), CHLOROTHIAZIDE, Chlorothiazide [Chemical/Ingredient], chlorothiazides, Chlorothiazide (product), Chlorothiazide (substance) |
Swedish | Klortiazid |
Czech | chlorthiazid |
Finnish | Klooritiatsidi |
Russian | KHLORTIAZID, KHLOROTIAZID, ХЛОРОТИАЗИД, ХЛОРТИАЗИД |
Croatian | Not Translated[Chlorothiazide] |
Spanish | Clorotiazida, Clorotiacida, clorotiazida (producto), clorotiazida (sustancia), clorotiazida |
Polish | Chlorotiazyd, Diuryl |
French | Chlorothiazide |
German | Chlorothiazid |
Italian | Clorotiazide |
Portuguese | Clorotiazida |