II. Indications

III. Dosing: Adults

  1. Oral (Hypertension or Edema)
    1. Start: 125-250 orally daily or divided twice daily
    2. Maximum: 500 mg orally twice daily
  2. Intravenous (Edema)
    1. IV Chlorothiazide is the only intravenous Thiazide Diuretic
    2. Dose: 0.5 to 1 mg IV daily to twice daily

IV. Pharmacokinetics

  1. Onset of activity <2 hours
  2. Duration: 6 to 12 hours

V. Mechanism

VI. Adverse Effects

VII. Safety

  1. Pregnancy Category C
    1. Pregnancy Category D if used for Pregnancy Induced Hypertension
  2. Considered Safe in Lactation

IX. References

  1. (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Ontology: Chlorothiazide (C0008273)

Definition (NCI) A short-acting, benzothiadiazinesulfonamide derivative and prototypical thiazide diuretic. Chlorothiazide is excreted unchanged by the kidneys.
Definition (MSH) A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
Definition (CSP) thiazide diuretic used to treat hypertension.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D002740
SnomedCT 372782002, 5786005
LNC LP16071-0, MTHU008128
English Chlorothiazide, 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide, chlorothiazide, chlorothiazide (medication), CHLOROTHIAZIDE, Chlorothiazide [Chemical/Ingredient], chlorothiazides, Chlorothiazide (product), Chlorothiazide (substance)
Swedish Klortiazid
Czech chlorthiazid
Finnish Klooritiatsidi
Russian KHLORTIAZID, KHLOROTIAZID, ХЛОРОТИАЗИД, ХЛОРТИАЗИД
Croatian Not Translated[Chlorothiazide]
Spanish Clorotiazida, Clorotiacida, clorotiazida (producto), clorotiazida (sustancia), clorotiazida
Polish Chlorotiazyd, Diuryl
French Chlorothiazide
German Chlorothiazid
Italian Clorotiazide
Portuguese Clorotiazida