II. Indications
III. Mechanism
- See ACE Inhibitor
- Carboxyl-containing Angiotensin-converting enzyme (ACE) inhibitor
- Benazapril is a prodrug, converted to its active form benazeprilat in the liver
IV. Dosing: Adults
- Adequate 24 hour control may require divided dosing twice daily
-
Hypertension
- Start 10 mg orally daily
- Start at 5 mg orally daily in elderly, Diuretic use, GFR <30
- Start at 5 mg in Congestive Heart Failure (CHF)
- Target 20-40 mg/day
- Start 10 mg orally daily
- Maximum: 80 mg/day (40 mg/day in CHF)
-
Renal Dosing
- GFR <30 ml/min: Start at 5 mg
V. Dosing: Children (age >=6 years old)
- Contraindicated if GFR <30 ml/min or age <6 years old
-
Hypertension
- Start 0.2 mg/kg/day up to 10 mg/day
- Maximum: 0.6 mg/day up to 40 mg/day
VI. Supplied
- Available as unscored generic tablets: 5, 10, 20 and 40 mg
VII. Metabolism
- Primarily renal excretion (as benzeprilat)
VIII. Adverse Effects
- See ACE Inhibitor
IX. Safety
- See ACE Inhibitor
- Pregnancy Category X
- Avoid in Lactation
X. Resources
XI. References
- (2016) Presc Lett, Resource #321151, ACE Inhibitor Antihypertensive Dose Comparison
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 68-9
- Hamilton (2020) Tarascon Pocket Pharmacopoeia