II. Indications
III. Dosing: Adults
- Start: 1.25 to 5 mg orally daily
- Maximum: 5 mg/day
IV. Efficacy
- Preferred over Hydrochlorothiazide
- Longer Half-Life (24 hours)
- May have cardiovascular benefit in elderly (CHF, CVA)
V. Pharmacokinetics
- Onset of activity 1 to 2 hours
- Duration >24 hours
VI. Mechanism
VII. Adverse Effects
VIII. Safety
- Pregnancy Category B
- Pregnancy Category D if used for Pregnancy Induced Hypertension
- Unknown Safety in Lactation
IX. Resources
X. References
- (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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indapamide (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
INDAPAMIDE 1.25 MG TABLET | Generic | $0.12 each |
INDAPAMIDE 2.5 MG TABLET | Generic | $0.12 each |
Ontology: Indapamide (C0021186)
Definition (MSH) | A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS. |
Definition (NCI) | An indole derivative of chlorosulphonamide and a sulfamyl diuretic with antihypertensive activity. Indapamide may interact directly with the subunits of delayed rectifier potassium channels, thereby blocking both slow and rapid K+ (IKs and IKr) currents through the channels. Through the homeostasis mechanism in balancing total ion concentration (Ca++, Na+), it reduces vascular hyperreactivity and peripheral and arterial vascular resistance, possibly by inhibiting transmembrane ionic influx, probably calcium ions, and stimulating prostaglandin E2 synthesis, thereby causing vasodilatation. Indapamide exerts its diuretic effect by inhibiting reabsorption of sodium and chloride, primarily as a result of action on the cortical diluting segment of the renal distal tubule, thereby promoting urinary excretion of water and electrolytes. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D007190 |
SnomedCT | 387419003, 74213004 |
English | Indapamide, Metindamide, Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-, indapamide, indapamide (medication), INDAPAMIDE, Indapamide [Chemical/Ingredient], Indapamide (product), Indapamide (substance) |
Swedish | Indapamid |
Czech | indapamid |
Finnish | Indapamidi |
Russian | INDAPAMID, METINDAMID, ИНДАПАМИД, МЕТИНДАМИД |
Japanese | インダパミド, メチンダミド |
Polish | Indapamid |
Spanish | indapamida (producto), indapamida (sustancia), indapamida, Indapamida, Metindamida |
French | Indapamide |
German | Indapamid, Metindamid |
Italian | Indapamide |
Portuguese | Indapamida, Metindamida |