II. Indications
III. Dosing: Adults
- Start: 1.25 to 5 mg orally daily
- Maximum: 5 mg/day
IV. Efficacy
- Preferred over Hydrochlorothiazide
- Longer Half-Life (24 hours)
- May have cardiovascular benefit in elderly (CHF, CVA)
V. Pharmacokinetics
- Onset of activity 1 to 2 hours
- Duration >24 hours
VI. Mechanism
VII. Adverse Effects
VIII. Safety
- Pregnancy Category B
- Pregnancy Category D if used for Pregnancy Induced Hypertension
- Unknown Safety in Lactation
IX. Resources
X. References
- (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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