III. Dosing: Adults

  1. Start: 1.25 to 5 mg orally daily
  2. Maximum: 5 mg/day

IV. Efficacy

  1. Preferred over Hydrochlorothiazide
    1. Longer Half-Life (24 hours)
    2. May have cardiovascular benefit in elderly (CHF, CVA)

V. Pharmacokinetics

  1. Onset of activity 1 to 2 hours
  2. Duration >24 hours

VI. Mechanism

VII. Adverse Effects

VIII. Safety

  1. Pregnancy Category B
    1. Pregnancy Category D if used for Pregnancy Induced Hypertension
  2. Unknown Safety in Lactation

X. References

  1. (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Related Studies

Cost: Medications

indapamide (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
INDAPAMIDE 1.25 MG TABLET Generic $0.12 each
INDAPAMIDE 2.5 MG TABLET Generic $0.12 each

Ontology: Indapamide (C0021186)

Definition (MSH) A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
Definition (NCI) An indole derivative of chlorosulphonamide and a sulfamyl diuretic with antihypertensive activity. Indapamide may interact directly with the subunits of delayed rectifier potassium channels, thereby blocking both slow and rapid K+ (IKs and IKr) currents through the channels. Through the homeostasis mechanism in balancing total ion concentration (Ca++, Na+), it reduces vascular hyperreactivity and peripheral and arterial vascular resistance, possibly by inhibiting transmembrane ionic influx, probably calcium ions, and stimulating prostaglandin E2 synthesis, thereby causing vasodilatation. Indapamide exerts its diuretic effect by inhibiting reabsorption of sodium and chloride, primarily as a result of action on the cortical diluting segment of the renal distal tubule, thereby promoting urinary excretion of water and electrolytes.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D007190
SnomedCT 387419003, 74213004
English Indapamide, Metindamide, Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-, indapamide, indapamide (medication), INDAPAMIDE, Indapamide [Chemical/Ingredient], Indapamide (product), Indapamide (substance)
Swedish Indapamid
Czech indapamid
Finnish Indapamidi
Russian INDAPAMID, METINDAMID, ИНДАПАМИД, МЕТИНДАМИД
Japanese インダパミド, メチンダミド
Polish Indapamid
Spanish indapamida (producto), indapamida (sustancia), indapamida, Indapamida, Metindamida
French Indapamide
German Indapamid, Metindamid
Italian Indapamide
Portuguese Indapamida, Metindamida