II. Indications

  1. Hypertension
    1. Not first-line Antihypertensives, and avoid using as monotherapy (higher risk of CVA and CHF)
  2. Benign Prostatic Hypertrophy
    1. Selective Alpha-1a Antagonists (e.g. Tamsulosin) are preferred
  3. Medical Expulsive Therapy for Ureteral Stone
    1. Replaced by the preferred Selective Alpha-1a Antagonists (e.g. Tamsulosin)

III. Dosing

  1. Hypertension
    1. Start 1 mg orally at bedtime
    2. Titrate to effective dose 1 to 5 mg daily or in divided doses
    3. Maximum 20 mg/day
  2. Benign Prostatic Hypertrophy (replaced by Selective Alpha-1a Antagonists)
    1. Start 1 mg orally at bedtime
    2. Titrate to effect by doubling dose every 1-2 weeks (to 2, 5 and 10 mg)
    3. Observe for effects after 4 to 6 weeks on optimal dose (typically 10 mg)
    4. Maximum of 20 mg/day

IV. Safety

  1. Pregnancy Category C
  2. Unknown safety in Lactation

V. Mechanism

  1. See Alpha Adrenergic Receptor (Alpha-1 Antagonist)
  2. Peripheral Alpha-1 Adrenergic Antagonist
    1. Arterial and Venous Vasodilation

VIII. References

  1. (2020) Med Lett Drugs Ther 62(1598): 73-80
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Related Studies

Cost: Medications

terazosin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
TERAZOSIN 1 MG CAPSULE Generic $0.14 each
TERAZOSIN 10 MG CAPSULE Generic $0.16 each
TERAZOSIN 2 MG CAPSULE Generic $0.14 each
TERAZOSIN 5 MG CAPSULE Generic $0.16 each

Ontology: Terazosin (C0076107)

Definition (NCI_NCI-GLOSS) A drug used to treat urinary problems caused by an enlarged prostate. It is also used to treat high blood pressure and is being studied in the treatment of other conditions. Terazosin relaxes muscle tissue in blood vessels and in the prostate. It is a type of alpha blocker.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C041226
SnomedCT 349914007, 129484001, 387068008
LNC LP101133-9, MTHU036183
English terazosin, Terazosin, Terazosin [Chemical/Ingredient], terazosine, TERAZOSIN, Terazosin (product), Terazosin (substance)
Spanish terazosina (producto), terazosina (sustancia), terazosina

Ontology: Hytrin (C0591628)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C041226
English Abbott Brand of Terazosin Hydrochloride, hytrin, hytrin bph, Hytrin, Hytrin BPH, Deflox, Flotrin, Heitrin, Hytrine