II. Dosing
- Standard Dose: 5-20 mg up to once daily, 1 hour prior to intercourse
- Adjusted maximum dosing
- Hepatic insufficiency: 10 mg
- Age over 65 years: 5 mg
III. Pharmacokinetics
- Onset 30-60 minutes
- Duration: 4-5 hours
IV. Contraindications
- See Phosphodiesterase Inhibitors (PDE5 Inhibitors)
- Men using nitrates (causes profound Hypotension)
- Men using alpha blockers (e.g. Hytrin for BPH)
V. Mechanism
VI. Drug Interactions
- See Phosphodiesterase Inhibitors (PDE5 Inhibitors)
- Profound Vasodilitation and Hypotension with Nitroglycerin and alpha blockers such as Prazosin (Avoid)
- Avoid Nitrates within 24 hours of Verdenadil (Levitra)
- Cytochrome P3A4 related interactions (Cimetidine, systemic Antifungals, Protease Inhibitors and Macrolides
VII. Adverse Effects: Viagra (but most apply to the PDE5 Class as a whole)
- See Phosphodiesterase Inhibitors (PDE5 Inhibitors)
- Hypotensive effect for men on Nitrates (Avoid)
- Vision effects (color Vision, Vision Loss)
- Sensorineural Hearing Loss
- Mild Headache
Images: Related links to external sites (from Bing)
Related Studies
Definition (NCI) | A benzenesulfonamide derivative and phosphodiesterase type 5 (PDE5) inhibitor with vasodilatory activity. Vardenafil selectively inhibits PDE5, thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. The inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, prolonging penile erection. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C426063 |
SnomedCT | 407979001, 404858007 |
LNC | LP100060-5, MTHU035877 |
English | vardenafil [Chemical/Ingredient], 1-(((3-(3,4-dihydro-5-methyl)-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine, vardenafil, VARDENAFIL, Vardenafil (product), Vardenafil (substance), Vardenafil |
Spanish | vardenafil (producto), vardenafil (sustancia), vardenafil |
Ontology: Levitra (C1174890)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C426063 |
English | Levitra, levitra, Bayer brand of vardenafil hydrochloride |