II. Indications
III. Mechanism
- Semisynthetic glucosaminoglycan
IV. Dosing
- Pentosan polysulfate 100 mg PO tid
V. Efficacy
- Symptoms improve as much as 50% in controlled trials
- Response may not be seen for 3 to 6 months
VI. Adverse Effects
- Diarrhea
- Dyspepsia
- Alopecia (reversible)
- Headache
- Rash
- Dizziness
- Abdominal Pain
- Liver function abnormalities (<4%)
-
Retinal damage (Pigmentary Maculopathy)
- Retinal pigment changes result in Blurred Vision and difficulty in adjusting to dim lighting
- Risk increases with prolonged use (25% of patients using Elmiron >15 years)
- Dilated Eye Exam is recommended for patients on Elmiron
- Pearce (2018) Ophthalm 125(11): 1793-802 [PubMed]
- (2018) presc lett 27(2): 10
VII. References
- Bade (1997) Br J Urol 79:168-71
- Parsons (1993) J Urol 150:845-8
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Related Studies
| elmiron (on 9/15/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ELMIRON 100 MG CAPSULE | $10.09 each | |