II. Indications

  1. Hypertension
    1. Not first-line Antihypertensives, and avoid using as monotherapy (higher risk of CVA and CHF)

III. Efficacy

  1. Terazosin and Doxazosin are preferred over Prazosin (once daily dosing at similar cost)

IV. Dosing

  1. Hypertension
    1. Start 1 mg orally twice daily to three times daily
    2. Titrate to usual daily total dose 20 mg divided two to three times daily
    3. Maximum total daily dose: 40 mg/day (but doses above 20 mg/day offer little additional benefit)

V. Safety

  1. Pregnancy Category C
  2. Unknown safety in Lactation

VI. Mechanism

  1. See Alpha Adrenergic Receptor (Alpha-1 Antagonist)
  2. Peripheral Alpha-1 Adrenergic Antagonist
    1. Arterial and Venous Vasodilation

VII. Adverse Effects

IX. References

  1. (2020) Med Lett Drugs Ther 62(1598): 73-80
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Related Studies

Cost: Medications

prazosin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
PRAZOSIN 1 MG CAPSULE Generic $0.18 each
PRAZOSIN 2 MG CAPSULE Generic $0.26 each
PRAZOSIN 5 MG CAPSULE Generic $0.50 each