Prazosin

Aka: Prazosin, Minipress

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II. Indications

  1. Hypertension
    1. Not first-line Antihypertensives, and avoid using as monotherapy (higher risk of CVA and CHF)

III. Efficacy

  1. Terazosin and Doxazosin are preferred over Prazosin (once daily dosing at similar cost)

IV. Dosing

  1. Hypertension
    1. Start 1 mg orally twice daily to three times daily
    2. Titrate to usual daily total dose 20 mg divided two to three times daily
    3. Maximum total daily dose: 40 mg/day (but doses above 20 mg/day offer little additional benefit)

V. Safety

  1. Pregnancy Category C
  2. Unknown safety in Lactation

VI. Mechanism

  1. See Alpha Adrenergic Receptor (Alpha-1 Antagonist)
  2. Peripheral Alpha-1 Adrenergic Antagonist
    1. Arterial and Venous Vasodilation

VII. Adverse Effects

  1. See Postsynaptic Alpha Adrenergic Antagonist

VIII. Resources

  1. Prazosin (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4db5fdc0-f5a2-49f0-8129-bad6e7c2f998

IX. References

  1. (2020) Med Lett Drugs Ther 62(1598): 73-80
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Related Studies

Cost: Medications

prazosin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
PRAZOSIN 1 MG CAPSULE Generic $0.18 each
PRAZOSIN 2 MG CAPSULE Generic $0.26 each
PRAZOSIN 5 MG CAPSULE Generic $0.50 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

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