II. Indications
-
Hypertension
- Weak Diuretic primarily used to counter urinary Potassium loss with other Diuretics
- Typically combined with Thiazide Diuretics (rarely used alone)
III. Contraindications
- Significant Renal Insufficiency
- Anuria
- Hyperkalemia
IV. Mechanism
- Potassium-Sparing Diuretics only (Aldosterone independent)
- Primarily used to counter urinary Potassium loss with other Diuretics (e.g. Thiazide Diuretics)
- Act directly at the distal convoluted tubule (Aldosterone independent)
V. Dosing
- Dose: 100 mg orally twice daily
- Maximum: 300 mg/day
- Typically used as Combination Medication with Thiazide Diuretic
- Diazide (37.5 to 50 mg Triamterene and 25 mg Hydrochlorothiazide)
- Maxide (75 mg Triamterene and 50 mg Hydrochlorothiazide)
VI. Pharmacokinetics
- Rapidly absorbed, highly metabolized in liver and Kidney and rapidly excreted
- Onset: 2 to 4 hours
- Duration: 7 to 9 hours
VII. Adverse Effects
- See Potassium-Sparing Diuretic
- Blue Urine Color
- Specific to Triamterene
VIII. Safety
- Pregnancy Category B
- Avoid in Lactation
IX. Resources
X. References
- (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
| triamterene (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| TRIAMTERENE-HYDROCHLOROTHIAZIDE 37.5-25 MG CP | Generic | $0.12 each |
| TRIAMTERENE-HYDROCHLOROTHIAZIDE 37.5-25 MG TB | Generic | $0.09 each |
| TRIAMTERENE-HYDROCHLOROTHIAZIDE 75-50 MG TAB | Generic | $0.13 each |