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Ontology:
Amiloride
(C0002502)
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Definition (NCI)
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A synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and collecting ducts of the kidney, thereby preventing the absorption of sodium and increasing its excretion along with water, to produce naturesis. In response to the hypernatremic conditions in the kidney, the plasma membrane becomes hyperpolarized and electrochemical forces are reduced, which then prevents the excretion of potassium and hydrogen into the lumen.
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Definition (CSP)
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pyrazine compound inhibiting sodium reabsorbtion through sodium channels in renal epithelial cells; used in conjunction with diuretics to spare potassium loss.
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Definition (MSH)
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A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D000584
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| SnomedCT |
387503008, 87395005 |
| LNC |
LP16024-9, MTHU006775 |
| English |
Amiloride, Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, Amiloride [Chemical/Ingredient], aMILoride, AMILORIDE, amiloride, Amipramizide, Amiloride (product), Amiloride (substance) |
| Swedish |
Amilorid
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| Czech |
amilorid
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| Finnish |
Amiloridi
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| Russian |
AMILORID, АМИЛОРИД |
| Croatian |
AMILORID
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| Polish |
Amiloryd
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| Japanese |
アミロライド, アミパミジン, アミロラジド, アミロリド |
| Spanish |
amilorida (producto), amilorida (sustancia), amilorida, Amilorida |
| French |
Amiloride
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| German |
Amilorid
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| Italian |
Amiloride
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| Portuguese |
Amilorida
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Ontology:
Midamor
(C0026054)
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D000584
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| English |
midamor, Cahill May Roberts Brand of Amiloride Hydrochloride, Merck Brand of Amiloride Hydrochloride, Merck Sharp & Dohme Brand of Amiloride Hydrochloride, Modamide, Midamor |
Ontology:
Triamterene
(C0040869)
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Definition (MSH)
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A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
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Definition (NCI)
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A pteridine derivative with potassium-sparing diuretic property. Triamterene blocks the sodium-potassium exchange pump (Na-K-ATPase) in the luminal membrane of principal cells in the late distal tubule, cortical collecting tubule and collecting duct in the kidney. This reversible inhibition of the electrogenic sodium transport decreases the lumen-negative transepithelial potential difference and thus reduces the driving force for K+ movement into the tubular lumen resulting in the inhibition of sodium reabsorption in exchange for K+ and H+.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D014223
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| SnomedCT |
12512008, 387053007 |
| LNC |
LP14734-5, MTHU001919 |
| English |
Triamterene, 2,4,7-Pteridinetriamine, 6-phenyl-, triamterene, triamterene (medication), TRIAMTERENE, Triamterene [Chemical/Ingredient], 6-Phenyl-2,4,7-triaminopteridine, 6-Phenyl-2,4,7-pteridinetriamine, Triamterene (product), Triamterene (substance) |
| Swedish |
Triamteren
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| Czech |
triamteren
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| Finnish |
Triamtereeni
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| Russian |
TRIAMTEREN, PTEROFEN, ПТЕРОФЕН, ТРИАМТЕРЕН |
| Japanese |
トリアムテレン
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| Polish |
Triamteren
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| Spanish |
triamtereno (producto), triamtereno (sustancia), triamtereno, Triantereno |
| French |
Triamtérène
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| German |
Triamteren
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| Italian |
Triamterene
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| Portuguese |
Triantereno
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Ontology:
Dyrenium
(C0700653)
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D014223
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| English |
Dyrenium, Wellspring Brand of Triamterene |
