II. Indications
- See Angiotensin Receptor Blocker
- Hypertension
- Cardiovascular Secondary Prevention
- Congestive Heart Failure (not FDA approved)
- Diabetic Nephropathy
III. Contraindications
IV. Mechanism
V. Dosing: Adults
- Consider twice daily divided dosing (shorter acting than newer ARBs)
-
Hypertension, Cardiovascular Secondary Prevention, Diabetic Nephropathy
- Start: 50 mg orally daily
- Start 25 mg daily if concurrent Diuretic use, elderly or hepatic Impairment
-
Congestive Heart Failure (not FDA approved)
- Start 12.5 mg orally daily
- Target 50 mg orally daily
- Maximum 100 mg/day
VI. Medications: Combinations
- Hydrochlorothiazide and Losartan (Hyzaar)
VII. Adverse Effects
VIII. Safety
- See Angiotensin Receptor Blocker
- Pregnancy Category X
- Unknown Safety in Lactation
X. Drug Interactions
- Losartan drug levels may be increased by potent CYP3A4 Inhibitors (e.g. Fluconazole, Erythromycin)
- Losartan drug levels may be decreased by potent CYP3A4 Inducers (e.g. Rifampin)
XI. Resources
XII. References
- (2018) Presc Lett, Resource #340901, Angiotensin Receptor Blocker (ARB) Antihypertensive Dose Comparison
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 66-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
losartan (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
LOSARTAN POTASSIUM 100 MG TAB | Generic | $0.08 each |
LOSARTAN POTASSIUM 25 MG TAB | Generic | $0.04 each |
LOSARTAN POTASSIUM 50 MG TAB | Generic | $0.05 each |
LOSARTAN-HYDROCHLOROTHIAZIDE 100-12.5 MG TAB | Generic | $0.13 each |
LOSARTAN-HYDROCHLOROTHIAZIDE 100-25 MG TAB | Generic | $0.14 each |
LOSARTAN-HYDROCHLOROTHIAZIDE 50-12.5 MG TAB | Generic | $0.12 each |
cozaar (on 1/14/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
COZAAR 100 MG TABLET | Generic | $0.08 each |
COZAAR 50 MG TABLET | Generic | $0.05 each |
hyzaar (on 2/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
HYZAAR 100-25 TABLET | Generic | $0.14 each |
HYZAAR 50-12.5 TABLET | Generic | $0.12 each |
Ontology: Losartan (C0126174)
Definition (CHV) | a drug used to treat hypertension |
Definition (CHV) | a drug used to treat hypertension |
Definition (NCI_NCI-GLOSS) | A drug used to treat high blood pressure. Losartan blocks the action of chemicals that make blood vessels constrict (get narrower). It is a type of angiotensin II receptor antagonist. |
Definition (NCI) | The potassium salt form of losartan, a non-peptide angiotensin II antagonist with antihypertensive activity. Losartan potassium selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor. Angiotensin II, formed from angiotensin I by angiotensin-converting enzyme (ACE), stimulates the adrenal cortex to synthesize and secrete aldosterone, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle. Losartan potassium, by blocking the binding of angiotensin II to the AT 1 receptor, promotes vasodilatation and decreases the effects of aldosterone. |
Definition (MSH) | An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II. |
Definition (CSP) | antihypertensive agent; nonpeptide angiotension 1 subtype; angiotension 2 receptor antagonist/inhibitor. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D019808 |
SnomedCT | 373567002, 96309000 |
LNC | LP171619-2 |
English | Losartan, lozartan, 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol, 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, Losartan [Chemical/Ingredient], LOSARTAN, losartan, Losartan (product), Losartan (substance) |
Swedish | Losartan |
Czech | losartan |
Finnish | Losartaani |
Russian | LOZARTAN, ЛОЗАРТАН |
Japanese | ロサルタン, ロザルタン |
Croatian | LOSARTAN |
Spanish | losartano, Losartán, losartano (sustancia), losartán (producto), losartán (sustancia), losartán |
Polish | Losartan |
French | Losartan |
Portuguese | Losartano, Losartan |
German | Losartan |
Italian | Losartan |
Ontology: Cozaar (C0591301)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D019808 |
English | cozaar, Cozaar |