II. Mechanism
- PCSK9 Small Interfering RNA
- Prevents translation of PCSK9 Protein
- As with PCSK9 Inhibitors, up regulates hepatic LDL receptors
- Results in increased LDL clearance from blood
- Lowers LDL 50% in combination with high dose Statin
III. Precautions
- Cost $6500/year in addition to clinic dosing administration cost
IV. Dosing: Inclisiran (Leqvio)
- Inclisiran SQ at 0, 3 and 6 months, then every 6 hours (in office)
V. References
- (2022) Presc Lett 29(2): 7-8