II. Indications

III. Mechanism

  1. Benzapine derivative that acts primarily as a selective Dopamine Agonist at peripheral DA1 receptors
    1. Also act at alpha-2 adrenoreceptors
  2. Vasodilation and Antihypertensive activity
  3. Also increases Prolactin release
  4. Promotes Sodium and water diuresis via increased vasodilation and renal Blood Flow

IV. Preparation

  1. Prepare 40 mcg/ml solution by diluting 10 mg in 250 ml D5W

V. Precautions

  1. Monitor Heart Rate and Blood Pressure closely (Intensive Care, emergency department)

VI. Dosing: Adults

  1. Start 0.1 mcg/kg/min (11 ml/h for a 70 kg patient)
  2. Titrate as needed every 15 min to 0.1 to 1.6 mcg/kg/min

VII. Dosing: Children

  1. Start 0.1 to 0.2 mcg/kg/min
  2. Titrate as needed every 20 to 30 min to 0.3 to 0.5 mcg/kg/min
  3. Maximum infusion rate: 0.8 mcg/kg/min
  4. Maximum duration: 4 hours

VIII. Adverse Effects

  1. Reflex Tachycardia
    1. More common with doses >0.1 mcg/kg/min
  2. Increased Intraocular Pressure
    1. Use caution in Glaucoma

IX. Drug Interactions

  1. Avoid with Beta Blockers (higher risk of Hypotension)

X. Metabolism

  1. Half-Life: 5 minutes

XI. Safety

  1. Pregnancy Category B
  2. Unknown safety in pregnancy

XIII. References

  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 68-9
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Ontology: Fenoldopam (C0060180)

Definition (NCI) A benzazepine derivative with vasodilatory and antihypertensive properties. Fenoldopam, a dopamine (DA) receptor agonist, binds specifically to peripheral DA1 receptors and to alpha-2 adrenoceptors with moderate affinity. However, this agent exhibits no significant affinity to DA2, other alpha adrenergic, beta adrenergic, muscarinic, or serotonergic receptors. Receptor binding modulates the transmembrane flux of ions, thereby stimulating adenylate cyclase activity, as well as the release of prolactin. This results in vasodilatation, increased renal blood flow thereby enhancing natriuresis and diuresis leading to a lowering in diastolic blood pressure.
Definition (MSH) A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.
Definition (CSP) 6-chloro-2,3,4,5-tetrahydro-1-(p-hydroxyphenyl) -3-benzazepine-7,8- diol; dopamine D1 agonist with diuretic and antihypertensive properties, used to treat congestive heart failure, chronic renal failure, and essential hypertension.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D018818
SnomedCT 108590002, 409138007
English Fenoldopam, 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-, fenoldopam, Fenoldopam [Chemical/Ingredient], FENOLDOPAM, Fenoldopam (substance), Fenoldopam (product)
Swedish Fenoldopam
Czech fenoldopam
Finnish Fenolidopaami
Russian FENOLDOPAM, ФЕНОЛДОПАМ
Japanese フェノルドパム
Polish Fenoldopam
Spanish fenoldopam (sustancia), fenoldopam, fenoldopam (producto), Fenoldopam
French Fénoldopam
German Fenoldopam
Italian Fenoldopam
Portuguese Fenoldopam

Ontology: Corlopam (C0600404)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D018818
English corlopam, Corlopam