II. Indications

III. Mechanism

  1. Benzapine derivative that acts primarily as a selective Dopamine Agonist at peripheral DA1 receptors
    1. Also act at alpha-2 adrenoreceptors
  2. Vasodilation and antihypertensive activity
  3. Also increases Prolactin release
  4. Promotes Sodium and water diuresis via increased vasodilation and renal Blood Flow

IV. Preparation

  1. Prepare 40 mcg/ml solution by diluting 10 mg in 250 ml D5W

V. Precautions

  1. Monitor Heart Rate and Blood Pressure closely (Intensive Care, emergency department)

VI. Dosing: Adults

  1. Start 0.1 mcg/kg/min (11 ml/h for a 70 kg patient)
  2. Titrate as needed every 15 min to 0.1 to 1.6 mcg/kg/min

VII. Dosing: Children

  1. Start 0.1 to 0.2 mcg/kg/min
  2. Titrate as needed every 20 to 30 min to 0.3 to 0.5 mcg/kg/min
  3. Maximum infusion rate: 0.8 mcg/kg/min
  4. Maximum duration: 4 hours

VIII. Adverse Effects

  1. Reflex Tachycardia
    1. More common with doses >0.1 mcg/kg/min
  2. Increased Intraocular Pressure
    1. Use caution in Glaucoma

IX. Drug Interactions

  1. Avoid with Beta Blockers (higher risk of Hypotension)

X. Metabolism

  1. Half-Life: 5 minutes

XI. Safety

  1. Pregnancy Category B
  2. Unknown safety in pregnancy

XIII. References

  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 68-9
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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