II. Causes: Cardiac Medications
- Methyldopa
- Clonidine
- Antiarrhythmic medications (esp. Type Ia such as Quinidine)
- Alpha adrenergic blockers (e.g. Prazosin, Doxazosin, Terazosin)
- Less common with Selective Alpha-1a Antagonist (e.g. Tamsulosin)
- Beta Blockers (e.g. Atenolol, Metoprolol)
- Alpha-Beta Blockers (Carvedilol, Labetalol)
- Diuretics (e.g. Furosemide) due to multiple mechanisms (Hypovolemia, Hypokalemia, Hypomagnesemia)
- Vasodilator medications
- Nitrates (Nitroglycerin)
- Hydralazine
- Dipyridamole (Persantine)
- Reserpine
- Other agents that are not associated with significant Orthostatic Hypotension
III. Causes: Genitourinary Medications
- Phosphodiesterase type 5 inhibitors (e.g. Sildenafil or Viagra)
- Anticholinergics (e.g. Oxybutynin or Ditropan)
- Flibanserin (Addyi)
IV. Causes: Neuropsychiatric Agents
- Tricyclic Antidepressants (e.g. Amitriptyline, Doxepin, Trazodone)
- Parkinsonism agents (Levodopa-Carbidopa, Bromocriptine)
- Barbiturates
- MAO Inhibitors (e.g. Phenelzine)
-
Antipsychotics (e.g. Chlorpromazine, Clozapine, Thioridazine)
- Second generation Antipsychotics are also associated with Orthostatic Hypotension
- Muscle relaxants (e.g. Baclofen, Cyclobenzaprine, Methocarbamol, Tizanidine)