Orthostatic Hypotension

Aka: Orthostatic Hypotension, Postural Hypotension, Orthostatic Blood Pressure, Orthostasis, Orthostatic Syncope, Postural Blood Pressure, Postural Pulse, Shellong Test, Postprandial Hypotension, Orthostatic Intolerance

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II. Definitions

  1. Orthostatic Hypotension
    1. Blood Pressure drop on standing of >20 mmHg systolic or 10 mHg diastolic
    2. Occurs within 3 minutes of standing from supine (or at 60 degrees on Tilt Table testing)
  2. Orthostatic Heart Rate
    1. Heart Rate increase on standing from supine of 30 beats per minute
    2. Occurs within 3 minutes of standing from supine
    3. Expected compensatory response that is lacking in neurogenic Orthostatic Hypotension
  3. Postprandial Hypotension
    1. Systolic Blood Pressure drop >20 mmHg from baseline >100 mmHg within 2 hours of a meal
  4. Orthostatic Intolerance
    1. Symptoms of cerebral hypoperfusion (e.g. Light Headedness) or autonomic hyperresponsiveness (e.g. Tachycardia)
    2. Symptoms occur when standing and relieved when supine
    3. Subtypes include neurogenic Orthostatic Hypotension, Postural Orthostatic Tachycardia Syndrome (POTS), Neurocardiogenic Syncope

III. Epidemiology

  1. Orthostatic Hypotension Prevalence increases with age and debility
    1. Middle Age: 5%
    2. Age > 60 years: 20%
    3. Nursing Home: 50%
    4. Geriatric medical ward: 68%
  2. Orthostatic Hypotension related hospital admissions (U.S., 2007)
    1. All adults: 36 per 100,000
    2. Adults>75 years: 233 per 100,000

IV. Physiology

  1. Event: Rising from lying to standing position
    1. Intravascular volume redistributes and 300 to 800 ml of blood pools in legs (and splanchnic circulation)
    2. Results in decreased venous return and decreased Cardiac Output
  2. Physiologic response
    1. Lower extremity Muscle Contraction compresses veins
    2. Autonomic response
      1. Baroreceptors sense change in Blood Pressure
        1. Carotid Sinuses (carotid arteries, via Glossopharyngeal Nerve)
        2. Aortic Baroreceptors (aortic arch, via Vagus Nerve)
      2. Sympathetic Nervous System response
        1. Increases vascular tone (Peripheral Vascular Resistance)
        2. Increases Heart Rate and cardiac contractility
    3. Orthostatic Hypotension causes
      1. Inadequate autonomic response (neurogenic) OR
      2. Insufficient intravascular volume or circulation (nonneurogenic)
  3. Modifiers
    1. Age
      1. Baroreceptor sensitivity decreases resulting in a delayed autonomic response
      2. Affects 20% in age > 60 years (but only 5% in middle aged adults, see above)
    2. Decreased Blood Volume or Dehydration
      1. Baroreceptors trigger increased renin and Vasopressin
      2. Results in increased Sodium and water reabsorption
    3. Postprandial Hypotension
      1. Systolic Blood Pressure drop >20 mmHg from baseline >100 mmHg within 2 hours of a meal
      2. More common in comorbid Diabetes Mellitus, other neurologic disorders and Hypertension
      3. Associated with higher risk of Syncope, increased coronary events and mortality

V. Risk Factors

  1. Older adults (esp. age >70 years)
  2. Polypharmacy
    1. See Medication Causes of Orthostatic Hypotension
  3. Peripheral Neuropathy
    1. Diabetic Neuropathy (most common)
    2. Amyloidosis
    3. HIV Infection
  4. Neurodegenerative disorders
    1. Lewy Body Dementia
    2. Multiple System Atrophy
    3. Parkinsonism
    4. Pure autonomic failure

VI. Symptoms

  1. May be asymptomatic
  2. Symptoms occur on standing from supine (or seated position) and are relieved on returning to supine position
    1. Symptoms are a result of transient Hypotension causing decreased end organ perfusion
  3. Dizziness or Light Headedness
  4. Chest Pain or Palpitations
  5. Orthostatic Syncope
  6. Nausea
  7. Pallor
  8. Weakness or Fatigue
  9. Dyspnea
  10. Blurred or dimmed Vision
  11. Neck or Shoulder Pain

VII. Exam

  1. See Head-Up Tilt Table Test
  2. Orthostatic Blood Pressure and Pulse (Shellong Test)
    1. Technique
      1. Supine Blood Pressure and pulse after lying for 5 minutes
      2. Standing Blood Pressure, pulse after 3 minutes standing, from supine position
    2. Interpretation
      1. Orthostatic Hypotension is present if Blood Pressure drops >=20 mmHg systolic or 10 mmHg diastolic
        1. In supine Hypertension, use systolic BP drop >=30 mmHg for diagnosis (see below)
      2. Heart Rate increase >30 bpm on standing from supine is suggestive of Orthostasis
        1. Compensatory Heart Rate is present in nonneurogenic Orthostasis (e.g. Dehydration)
        2. Compensatory Heart Rate is ABSENT in neurogenic Orthostasis (defective autonomic response)
        3. Heart Rate increases without BP drop in Postural Orthostatic Tachycardia Syndrome (POTS)
  3. Supine Hypertension
    1. Systolic BP >140 mmHg or Diastolic BP >90 mmHg after 5 minutes in supine position
    2. If supine Hypertension is present, use systolic BP drop >=30 mmHg for Orthostatic Hypotension diagnosis
    3. Supine Hypertension affects >50% of patients with neurogenic Orthostatic Hypotension
      1. Often worsened with Antihypertensive medications
  4. Response to 15 second Valsalva Maneuver
    1. Normally Blood Pressure falls, then rises over baseline
    2. Abnormal if Blood Pressure does not overshoot baseline
  5. Pulse variation on deep breathing (sinus Arrhythmia)
    1. Normal response
      1. Tachycardia on inspiration
      2. Bradycardia on expiration
    2. Abnormal if <9 beat/min difference during cycle

VIII. Efficacy: Orthostatic Blood Pressure and Pulse as a Hydration Marker

  1. Orthostatic Vital Signs have low utility and other measures should be used to assess volume status
    1. Swaminathan In Herbert (2013) EM: Rap 13(11): 6-7
  2. Orthostatic Blood Pressure and pulse are poor indicators of Hypovolemia in Hemorrhage and Dehydration
    1. McGee (1999) JAMA 281(11): 1022-9 [PubMed]
    2. Johnson (1995) Acad Emerg Med 2(8):692-7 [PubMed]
  3. Orthostasis is present in as many as 20-50% of those over age 65 years (and typically asymptomatic)
    1. Rutan (1992) Hypertension 19(6 pt 1): 508-19 [PubMed]
    2. Ooi (1997) JAMA 277(16):1299-304 [PubMed]

IX. Causes: Neurogenic

  1. See Autonomic Dysfunction
  2. Background
    1. Inadequate autonomic response to standing from supine
    2. Compensatory Heart Rate response to standing is typically ABSENT
    3. May be associated with neurologic deficits (e.g. Parkinsonism, Dementia, Ataxia)
    4. May be associated with autonomic failure symptoms (e.g. Postprandial Hypotension, morning symptoms)
    5. Associated with supine Hypertension in >50% of cases (see exam above)
  3. Trauma or mass
    1. Spinal Cord Injury
    2. Traumatic Brain Injury
    3. Syringomyelia
  4. Infectious and Inflammatory
    1. Tabes Dorsalis
    2. Human Immunodeficiency Virus (HIV)
  5. Autonomic alpha-synucleinopathy
    1. Lewy Body Dementia
    2. Multiple System Atrophy
    3. Parkinsonism
    4. Pure Autonomic Failure
  6. Peripheral Autonomic Disorders
    1. Diabetic Neuropathy
    2. Amyloidosis
    3. Alcohol Abuse
    4. Vitamin B12 Deficiency (Pernicious Anemia)
    5. Postprandial Hypotension (occurs within 2 hours of a meal)
  7. Carotid Sinus Hypersensitivity
    1. Cardioinhibitory Syncope
    2. Vasodepressor Syncope
  8. Miscellaneous
    1. Guillain-Barre Syndrome
    2. Post-sympathectomy
    3. Idiopathic Orthostatic Hypotension
    4. Shy-Drager Syndrome

X. Causes: Non-Neurogenic

  1. Background
    1. Inadequate cardiovascular response to standing from supine
    2. Compensatory Heart Rate response to standing is typically PRESENT (Heart Rate increases)
      1. Expect Heart Rate increase of at least 0.5 bpm per mmHg decrease in systolic Blood Pressure
      2. Norcliffe-Kaufmann (2018) Ann Neurol 83(3): 522-31 [PubMed]
  2. Medications
    1. See Medication Causes of Orthostatic Hypotension
  3. Cardiogenic
    1. Myocardial Infarction
    2. Arrhythmia
    3. Aortic Stenosis
    4. Myocarditis
    5. Pericarditis
    6. Bradycardia
    7. Congestive Heart Failure
  4. Hypovolemia (Tachycardia present, most common)
    1. Dehydration
    2. Hemorrhage
    3. Sepsis (Distributive Shock)
    4. Anemia
    5. Burn Injury
    6. Adrenal Insufficiency
    7. Diabetes Insipidus
    8. Hyperglycemia
    9. Straining
      1. Heavy lifting
      2. Urinating (Micturition Syncope)
  5. Venous pooling
    1. Venous Insufficiency
    2. Prolonged bed rest
    3. Strenuous Exercise
    4. Fever
    5. Sepsis
    6. Heat exposure
    7. Alcohol Intoxication
    8. Pregnancy or postpartum
  6. Miscellaneous causes
    1. Aging (esp. age >70 years)
    2. Hypokalemia
    3. Hypothyroidism

XI. Differential Diagnosis

  1. See Hypotension
  2. See Syncope
  3. Orthostatic Intolerance
    1. Symptoms of Orthostasis that make upright Posture difficult to maintain
    2. Postural Orthostatic Tachycardia Syndrome (POTS)
      1. Symptoms of Orthostasis with Tachycardia, but insignificant Hypotension
    3. Neurocardiogenic Syncope
  4. Postprandial Hypotension
    1. More common in Diabetes Mellitus
    2. Responds to small, frequent low Carbohydrate meals, multiple times daily
    3. Also consider Caffeine or Acarbose taken with meal

XII. Labs

  1. Basic metabolic panel (Electrolytes, Renal Function tests, Serum Glucose)
  2. Complete Blood Count
  3. Serum Vitamin B12
  4. Electrocardiogram (EKG)
  5. Thyroid Stimulating Hormone (TSH)
  6. Consider morning Cortisol level
  7. Consider Holter Monitor if unexplained symptoms

XIII. Imaging

  1. Head CT or Head MRI
  2. Echocardiogram

XIV. Evaluation

  1. See Head-Up Tilt Table Test
  2. Consider intravascular volume replacement (IV Fluids) in nonneurogenic Orthostasis
  3. Consider causes above (including Medication Causes of Orthostatic Hypotension)
  4. Evaluate for supine Hypertension (see above)
    1. Consider 24 hour Ambulatory Blood Pressure Monitoring in supine Hypertension

XV. Complications

  1. Orthostatic Syncope
  2. Orthostatic Hypotension is associated with increased Cardiovascular Risks and mortality
    1. Increased risks of Myocardial Infarction and Congestive Heart Failure
    2. Increased Fall Risk
    3. Increased mortality
    4. Ricci (2015) Eur Heart J 36(25): 1609-17 [PubMed]
    5. Federowski (2010) Eur Heart J 31(1): 85-91 [PubMed]

XVI. Management

  1. General goals
    1. Reduce symptoms and improve quality of life
    2. Interventions are not intended to normalize Blood Pressure to a specific number
  2. Avoid medications related to Orthostasis (e.g. Opioids, psychoactive agents, Anticholinergic Medications)
    1. See Medication Causes of Orthostatic Hypotension
    2. Decrease dose or change medication to one less likey to cause Orthostatic Hypotension
      1. Consider stopping Tricyclic Antidepressants, Antipsychotics
    3. Consider nighttime dosing of Antihypertensives
  3. Treat underlying causes
    1. Correct Anemia
    2. Correct Vitamin B12 Deficiency
    3. Correct Hypothyroidism
    4. Correct Electrolyte abnormalities (e.g. Hypokalemia)
    5. Optimize Blood Sugar management in Diabetes Mellitus (see Diabetic Neuropathy)
  4. Modify diet
    1. Increase salt
      1. Maintain at least 2 to 3 grams Sodium daily
      2. Studies in POTS Syndrome use up to 8 to 10 g/day of Sodium
      3. Consider supplement up to 1-2 grams extra-per day (avoid in CHF, Edematous States)
      4. Target 24 hour urinary Sodium >170 mmol Sodium in 24 hours
    2. Increase water intake (>64 ounces or >2 Liters daily)
      1. Target >1500 ml Urine Output daily
      2. Pre-hydrate before triggering activity (e.g. 1-2 glasses of water before standing)
    3. Avoid or limit Alcohol
    4. Eat smaller, more frequent meals (avoid large Carbohydrate rich meals)
      1. Reduces risk of Postprandial Hypotension
      2. Postprandial Hypotension may also respond to Acarbose (Alpha-Glucosidase Inhibitor)
  5. Modify activity
    1. Avoid excessive heat exposure
    2. General activity and Exercise should be encouraged
      1. However, avoid Exercise with frequent position changes or very strenuous Exercise
      2. Gradually advance
    3. Sleep with head of bed slightly elevated to 30 to 45 degrees
      1. Variable evidence
    4. Rise from bed slowly allowing for equilibration
      1. Stand by edge of bed for 1-2 minutes before walking (allows for safety of returning to bed to prevent a fall)
    5. Avoid standing for long periods of time
    6. Isometric Exercises
      1. Work arms, legs and abdominal Muscles (e.g. toe raises, thigh contractions, forward flexion at waist)
    7. While standing, move frequently and stand with crossed legs (consider leaning forward)
    8. Squatting will also help maintain upright Posture
    9. Avoid work with arms above Shoulder height
    10. Dorsiflex feet several times before standing
    11. Consider graded Compression Stockings (30 to 40 mmHg)
      1. However, no significant evidence of benefit
  6. Consider medication therapy (esp. for neurologic causes)
    1. Review precautions before using
    2. Consult specialty care (e.g. neurology, cardiology)
    3. Fludrocortisone (Florinef)
      1. Synthetic Mineralocorticoid that increases Sodium and water retention
      2. Also increases vascular alpha-adrenergic Receptor Sensitivity resulting in Vasoconstriction
      3. Precaution
        1. Monitor for Hypokalemia and Hypertension
        2. Risk of edema and Congestive Heart Failure exacerbation
        3. Risk of longterm Left Ventricular Hypertrophy and Renal Failure
      4. Start at 0.1 mg daily, titrate weekly by 0.1 mg to maximum of 1mg daily
      5. Target
        1. Improved symptoms
        2. Significant Edema
        3. Weight gain > 3.6 kg
    4. Midodrine (ProAmitine)
      1. Limit to specialist use (FDA recommends removing from market due to lack efficacy)
      2. Short acting alpha-1 Adrenergic Agonist results in Vasoconstriction (increased Peripheral Vascular Resistance)
      3. Consider as alternative to Fludrocortisone in edematous conditions (e.g. Congestive Heart Failure)
      4. Increases Blood Pressure for 2-3 hours
      5. Risk of supine Hypertension (take at least 3-5 hours before bedtime)
      6. Contraindicated in Coronary Artery Disease, Hyperthyroidism, Acute Renal Failure
      7. Start at 2.5 three times daily, titrate weekly by 2.5 mg to maximum dose of 10 mg three times daily
      8. Adverse effects include Urinary Retention and piloerection (goose bumps)
    5. Northera (droxidopa)
      1. Very expensive ($7800/month) compared to other agents listed above (e.g. Fludrocortisone is $35/month)
      2. Short-acting Norepinephrine precursor that like Midodrine increases Peripheral Vascular Resistance
      3. Similar risks to Midodrine
      4. Start at 100 mg orally three times daily and titrate up to maximum of 600 mg orally three times daily
      5. Adverse effects include Headache, Nausea and Hypertension
  7. Other adjunctive medications
    1. Pyridostigmine (Mestinon)
      1. Start at 30 mg bid to tid and titrate to symptom control or up to 60 mg three times daily
    2. Atomoxetine (Strattera)
      1. Dosing: 18 mg orally once daily

XVII. References

  1. (2017) Presc Lett 24(2): 10
  2. (2022) Presc Lett 29(10): 60
  3. Engstrom (1997) Am Fam Physician 56(5):1378-84 [PubMed]
  4. Kim (2022) Am Fam Physician 105(1): 39-49 [PubMed]
  5. Lanier (2011) Am Fam Physician 84(5): 527-36 [PubMed]
  6. Low (2015) J Clin Neurol 11(3):220-6 +PMID:26174784 [PubMed]
  7. Mathias (1995) Neurology 45:S6-11 [PubMed]

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Related Studies

Ontology: Hypotension, Orthostatic (C0020651)

Definition (MSHCZE) Pokles tlaku krve objevující se při přechodu do vzpřímené polohy. Může způsobit přechodnou poruchu prokrvení mozku s krátkým bezvědomím (synkopou) nebo pocitem závrati či nejistoty. Příč. nervové poruchy např. diabetická neuropatie, některé léky např. některá antihypertenziva, značná ztráta krve, selhání nadledvin, dlouhodobý pobyt na lůžku aj. Prevencí při těchto stavech je opatrné a postupné vstávání. (cit. Velký lékařský slovník online, 2013 http://lekarske.slovniky.cz/ )
Definition (NCI) Sudden fall of the blood pressure of at least 20/10 mm Hg when a person stands up.
Definition (CSP) fall in blood pressure associated with dizziness, syncope and blurred vision occurring upon standing or when standing motionless in a fixed position.
Definition (MSH) A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
Concepts Finding (T033)
MSH D007024
ICD9 458.0
ICD10 I95.1
SnomedCT 155488005, 28651003
English Hypotension, Postural, HYPOTENSION ORTHOSTATIC, HYPOTENSION POSTURAL, Orthostatic hypo-tension, Hypotension, Orthostatic, Orthostatic Hypotension, orthostatic hypotension, orthostatic hypotension (physical finding), orthostatic hypotension (diagnosis), orthostatic hypotension was observed, Hypotension orthostatic, Hypotension postural, HYPOTENSION, ORTHOSTATIC, Postural Hypotension, Hypotension, postural, Hypotension, Orthostatic [Disease/Finding], hypotension postural, Hypotension;orthostatic, Hypotension;postural, hypotension orthostatic, Orthostatic hypotension, Postural hypotension, Orthostatic hypotension (disorder), hypotension; orthostatic, hypotension; postural, orthostatic; hypotension, postural; hypotension, Hypotension, orthostatic, postural hypotension
French HYPOTENSION ORTHOSTATIQUE, Hypotension orthostatique, Hypotension posturale
Portuguese HIPOTENSAO ORTOSTATICA, HIPOTENSAO POSTURAL, Hipotensão ortostática, Hipotensão Ortostática, Hipotensão Postural
Spanish HIPOTENSION ORTOSTATICA, HIPOTENSION POSTURAL, Hipotensión postural, hipotensión arterial ortostática (trastorno), hipotensión arterial ortostática, hipotensión arterial postural, Hipotensión ortostática, Hipotensión Ortostática, Hipotensión Postural
Dutch orthostatische hypotensie, houdingsafhankelijke hypotensie, hypotensie houdingsafhankelijk, houdingsafhankelijk; hypotensie, hypotensie; houdingsafhankelijk, hypotensie; orthostatisch, orthostatisch; hypotensie, Orthostatische hypotensie, Hypotensie, orthostatische, Hypotensie, posturale
German lageabhaengige Hypotonie, Hypotonie lageabhaengig, HYPOTONIE LAGEABHAENGIG, HYPOTONIE ORTHOSTATISCH, Orthostatische Hypotonie, Orthostasesyndrom, Hypotonie, orthostatische, Positionshypotonie
Swedish Hypotoni, ortostatisk
Japanese ｷﾘﾂｾｲﾃｲｹﾂｱﾂ, ﾀｲｲｾｲﾃｲｹﾂｱﾂ, 起立性低血圧, 低血圧-起立性, 体位性低血圧, 立ち眩み, 体位性低血圧症, 立ちくらみ, 起立性低血圧症
Finnish Ortostaattinen hypotensio
Russian GIPOTENZIIA ORTOSTATICHESKAIA, GIPOTENZIIA POSTURAL'NAIA, ГИПОТЕНЗИЯ ОРТОСТАТИЧЕСКАЯ, ГИПОТЕНЗИЯ ПОСТУРАЛЬНАЯ
Czech Posturální hypotenze, Ortostatická hypotenze, Hypotenze ortostatická, hypotenze ortostatická, posturální hypotenze, ortostatická hypotenze
Italian Ipotensione posturale, Ipotensione ortostatica
Korean 기립성 저혈압
Polish Niedociśnienie ortostatyczne, Hipotonia ortostatyczna
Hungarian Orthostatikus hipotenzió, Hypotensio orthostatica, Orthostatikus alacsony vérnyomás, Orthostatikus hypotensio
Norwegian Ortostatisk hypotensjon
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Orthostasis (C0149746)

Concepts Sign or Symptom (T184)
MSH D004244
Portuguese Ortoestase
Spanish Ortostasis
French Orthostase
German Orthostase
English orthostasis, Orthostasis
Italian Ortostasi
Norwegian Blodtrykksfall i oppreist stillling, Ortostatisme
Czech závratě při napřímení, vzpřímený postoj, ortostatický pokles tlaku
Dutch Orthostasis
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Orthostatic intolerance (C1535893)

Definition (MSH) Symptoms of cerebral hypoperfusion or autonomic overaction which develop while the subject is standing, but are relieved on recumbency. Types of this include NEUROCARDIOGENIC SYNCOPE; POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME; and neurogenic ORTHOSTATIC HYPOTENSION. (From Noseworthy, JH., Neurological Therapeutics Principles and Practice, 2007, p2575-2576)
Definition (NCI) A condition characterized by development of symptoms while standing. It is an autonomic nervous system disorder and the symptoms are relieved once the person sits back down. Symptoms include heart palpitations, sweating, anxiety, lightheadedness, hyperpnea, anxiety, and blurred vision.
Concepts Finding (T033)
MSH D054971
Dutch orthostatische intolerantie
Portuguese Intolerância ortostática, Intolerância Ortostática
Spanish Intolerancia ortostática, Intolerancia Ortostática
Japanese 起立不耐性, ｷﾘﾂﾌﾀｲｾｲ
English Orthostatic intolerance, Orthostatic Intolerance, Intolerance, Orthostatic, Orthostatic Intolerance [Disease/Finding]
Czech Ortostatická netolerance, ortostatická intolerance
French Intolérance orthostatique, Intolérance à la station debout
Italian Intolleranza ortostatica
Russian ОРТОСТАТИЧЕСКАЯ НЕПЕРЕНОСИМОСТЬ, ORTOSTATICHESKAIA NEPERENOSIMOST', ОРТОСТАТИЧЕСКАЯ ИНТОЛЕРАНТНОСТЬ, ORTOSTATICHESKAIA INTOLERANTNOST'
German Orthostatische Intoleranz, orthostatische Intoleranz
Swedish Ortostatisk intolerans
Polish Nietolerancja ortostatyczna
Hungarian Orthostatikus intolerantia
Norwegian Ortostatisk intoleranse
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Syncope due to orthostatic hypotension (C2316624)

Concepts Disease or Syndrome (T047)
SnomedCT 432524006
English Syncope due to orthostatic hypotension (disorder), Syncope due to orthostatic hypotension
Spanish síncope debido a hipotensión ortostática (trastorno), síncope debido a hipotensión ortostática
Derived from the NIH UMLS (Unified Medical Language System)

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