II. Indications

III. Mechanism

  1. Alpha Agonist: constricts arterioles and veins
  2. Increases peripheral resistance

IV. Efficacy

  1. Study: n=162, PCT
    1. Significantly improved standing BP and symptoms
  2. Reference
    1. Low (1997) JAMA 277:1046-51 [PubMed]

V. Adverse Effects

  1. Pilomotor reactions
  2. Urinary urgency and retention
  3. Supine Hypertension

VI. Dosing

  1. Dose: 10 mg PO tid

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Cost: Medications

midodrine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
MIDODRINE HCL 10 MG TABLET Generic $0.36 each
MIDODRINE HCL 2.5 MG TABLET Generic $0.19 each
MIDODRINE HCL 5 MG TABLET Generic $0.22 each