II. Indications

III. Mechanism

  1. Synthetic Anticholinergic, carboxylic acid derivative
  2. Selective Acetylcholine blockade of Muscarinic Receptors on Smooth Muscles
    1. Results in Smooth Muscle relaxation and antispasmodic activity
  3. Effects
    1. Relaxes gastrointestinal Smooth Muscle and decreases spasm
    2. Inhibits gastrointestinal motility
    3. Decreases gastric acid secretion
    4. Decreases Saliva and brochial secretions

IV. Dosing: Adult

  1. Start 20 mg orally four times daily as needed
  2. Increase to 40 mg orally four times daily as needed
    1. Typical effective dose (160 mg/day)

V. Dosing: Child

  1. Not FDA approved

VI. Adverse Effects

VII. Safety

  1. Pregnancy Category B
  2. Unknown safety in Lactation

IX. References

  1. (2020) Med Lett Drugs Ther 62(1594): 41-58
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Cost: Medications

dicyclomine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
DICYCLOMINE 10 MG CAPSULE Generic $0.13 each
DICYCLOMINE 10 MG/5 ML SOLN Generic $0.20 per ml
DICYCLOMINE 20 MG TABLET Generic $0.15 each