II. Indications

III. Mechanism

  1. Synthetic Anticholinergic, carboxylic acid derivative
  2. Selective Acetylcholine blockade of Muscarinic Receptors on Smooth Muscles
    1. Results in Smooth Muscle relaxation and antispasmodic activity
  3. Effects
    1. Relaxes gastrointestinal Smooth Muscle and decreases spasm
    2. Inhibits gastrointestinal motility
    3. Decreases gastric acid secretion
    4. Decreases Saliva and brochial secretions

IV. Dosing: Adult

  1. Start 20 mg orally four times daily as needed
  2. Increase to 40 mg orally four times daily as needed
    1. Typical effective dose (160 mg/day)

V. Dosing: Child

  1. Not FDA approved

VI. Adverse Effects

VII. Safety

  1. Pregnancy Category B
  2. Unknown safety in Lactation

IX. References

  1. (2020) Med Lett Drugs Ther 62(1594): 41-58
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Related Studies

Cost: Medications

dicyclomine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
DICYCLOMINE 10 MG CAPSULE Generic $0.13 each
DICYCLOMINE 10 MG/5 ML SOLN Generic $0.20 per ml
DICYCLOMINE 20 MG TABLET Generic $0.15 each

Ontology: Dicyclomine (C0012125)

Definition (NCI) A carboxylic acid derivative and a selective anticholinergic with antispasmodic activity. Dicyclomine blocks acetylcholine from binding to muscarinic receptors on smooth muscle. This agent has a direct relaxing effect on smooth muscle and therefore prevents spasms in the muscles of the gastrointestinal tract, inhibits gastrointestinal propulsive motility, decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretion.
Definition (MSH) A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004025
SnomedCT 372732007, 41493007
LNC LP18946-1, MTHU006967
English Dicyclomine, Dicycloverin, (1,1'-Bicyclohexyl)-1-carboxylic acid, 2-(diethylamino)ethyl ester, Dicyclomine [Chemical/Ingredient], DICYCLOMINE, dicycloverin, dicycloverine, dicyclomine, Dicyclomine (product), Dicyclomine (substance), Dicycloverine
Swedish Dicyklomin
Czech dicyklomin
Finnish Disyklomiini
Russian DITSIKLOMIN, DITSIKLOVERIN, ДИЦИКЛОВЕРИН, ДИЦИКЛОМИН
Japanese ジシクロミン, マーゲサンP, ジサイクロベリン, ベンチル, レスポリミン, ジシクロベリン, ベンチロール, 塩酸ジシクロベリン, 塩酸ジサイクロミン
Italian Dicicloverina, Diciclomina
Polish Dicykloweryna
Spanish diciclomina (producto), diciclomina (sustancia), diciclomina, Diciclomina, Dicicloverina
French Dicyclovérine
German Dicyclomin, Dicycloverin
Portuguese Diciclomina, Dicicloverina

Ontology: Bentyl (C0700023)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004025
English bentyl, Bentyl, Aventis Behring Brand of Dicyclomine Hydrochloride