II. Indications
III. Mechanism
- Synthetic Anticholinergic, carboxylic acid derivative
- Selective Acetylcholine blockade of Muscarinic Receptors on Smooth Muscles
- Results in Smooth Muscle relaxation and antispasmodic activity
- Effects
- Relaxes gastrointestinal Smooth Muscle and decreases spasm
- Inhibits gastrointestinal motility
- Decreases gastric acid secretion
- Decreases Saliva and brochial secretions
IV. Dosing: Adult
- Start 20 mg orally four times daily as needed
- Increase to 40 mg orally four times daily as needed
- Typical effective dose (160 mg/day)
V. Dosing: Child
- Not FDA approved
VI. Adverse Effects
VII. Safety
- Pregnancy Category B
- Unknown safety in Lactation
VIII. Resources
IX. References
- (2020) Med Lett Drugs Ther 62(1594): 41-58
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
dicyclomine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
DICYCLOMINE 10 MG CAPSULE | Generic | $0.13 each |
DICYCLOMINE 10 MG/5 ML SOLN | Generic | $0.20 per ml |
DICYCLOMINE 20 MG TABLET | Generic | $0.15 each |
Ontology: Dicyclomine (C0012125)
Definition (NCI) | A carboxylic acid derivative and a selective anticholinergic with antispasmodic activity. Dicyclomine blocks acetylcholine from binding to muscarinic receptors on smooth muscle. This agent has a direct relaxing effect on smooth muscle and therefore prevents spasms in the muscles of the gastrointestinal tract, inhibits gastrointestinal propulsive motility, decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretion. |
Definition (MSH) | A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D004025 |
SnomedCT | 372732007, 41493007 |
LNC | LP18946-1, MTHU006967 |
English | Dicyclomine, Dicycloverin, (1,1'-Bicyclohexyl)-1-carboxylic acid, 2-(diethylamino)ethyl ester, Dicyclomine [Chemical/Ingredient], DICYCLOMINE, dicycloverin, dicycloverine, dicyclomine, Dicyclomine (product), Dicyclomine (substance), Dicycloverine |
Swedish | Dicyklomin |
Czech | dicyklomin |
Finnish | Disyklomiini |
Russian | DITSIKLOMIN, DITSIKLOVERIN, ДИЦИКЛОВЕРИН, ДИЦИКЛОМИН |
Japanese | ジシクロミン, マーゲサンP, ジサイクロベリン, ベンチル, レスポリミン, ジシクロベリン, ベンチロール, 塩酸ジシクロベリン, 塩酸ジサイクロミン |
Italian | Dicicloverina, Diciclomina |
Polish | Dicykloweryna |
Spanish | diciclomina (producto), diciclomina (sustancia), diciclomina, Diciclomina, Dicicloverina |
French | Dicyclovérine |
German | Dicyclomin, Dicycloverin |
Portuguese | Diciclomina, Dicicloverina |
Ontology: Bentyl (C0700023)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D004025 |
English | bentyl, Bentyl, Aventis Behring Brand of Dicyclomine Hydrochloride |