II. Indications
III. Contraindications
- Porphyria
- Phenobarbital Hypersensitivity
IV. Mechanism
-
Barbiturate with 2 active metabolites
- Phenobarbital
- Phenylethylmalonamide (PEMA)
- Raises Seizure threshold
V. Dosing: adults and children over age 8 years
- Titration to maintenance dose
- Days 1 to 3: Take 100-125 mg PO qhs
- Days 4 to 6: Take 100-125 mg PO bid
- Days 7 to 9: Take 100-125 mg PO tid
- Days >10: Take 250 mg PO tid
- Maintenance dosing
- Standard dosing: 250 mg PO tid-qid
- Maximum dosing: 500 mg PO qid (do not exceed)
VI. Monitoring: Labs every 6 months
- Complete Blood Count
- Chemistry panel (SMA-12)
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PRIMIDONE 250 MG TABLET | Generic | $0.29 each |
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