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Definition (NCI)
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An analog of phenobarbital with antiepileptic property. Although the mechanism of action has not been fully elucidated, primidone probably exerts its actions, in a manner similar to phenobarbital, via activation of gamma-aminobutyric acid (GABA)-A receptor/chloride ionophore complex, which leads to prolonged and increased frequency of opening of the chloride channel within the receptor complex. This results in an alteration in the electrical activity of the nerve cell membrane, causing hyperpolarization and prevention of partial and tonic-clonic seizures. In addition, this agent is partially metabolized to phenobarbital and phenylethylmalonamide (PEMA), which may also contribute to its anti-seizure properties.
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Definition (MSH)
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An antiepileptic agent related to the barbiturates; it is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite. Adverse effects are reported to be more frequent than with PHENOBARBITAL. (From Martindale, The Extra Pharmacopoeia, 30th ed, p309)
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D011324
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| SnomedCT |
371193009, 387256009, 47120002 |
| LNC |
LP14730-3, MTHU003369 |
| English |
Primidone, Desoxyphenobarbital, Misodine, 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-phenyl-, 2-Deoxyphenobarbital, Mysedon, primidone, PRIMIDONE, primidone (medication), Primidone [Chemical/Ingredient], Primidone product (product), Primidone product, Hexamidinum, Primidone (product), Primidone (substance) |
| Swedish |
Primidon
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| Czech |
primidon
|
| Finnish |
Primidoni
|
| Russian |
DEZOKSIFENOBARBITAL, PRIMIDON, GEKSAMIDIN, PRIMAKLON, ГЕКСАМИДИН, ДЕЗОКСИФЕНОБАРБИТАЛ, ПРИМАКЛОН, ПРИМИДОН |
| Japanese |
プリマクロン, デスオキシフェノバルビタール, プリミドン |
| Polish |
Prymidon, Mizodin |
| Spanish |
primidona, producto, primidona, producto (producto), desoxifenobarbital, primidona (producto), primidona (sustancia), primidona, Primidona, Desoxifenobarbital |
| French |
Désoxyphenobarbitone, Primaclone, Primidone |
| German |
Desoxyphenobarbital, Primidon |
| Italian |
Primidone
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| Portuguese |
Desoxifenobarbital, Primidona |
