II. Indication
- Alzheimer's Disease related Dementia
III. Mechanism
- Acetylcholinesterase Inhibitor
- Acts also at Nicotinic Receptors
- Derived from Daffodil bulbs
IV. Pharmacokinetics
V. Dosing
- May require concurrent Antiemetic use
- Immediate Release
- Start: 4 mg orally twice daily with breakfast and dinner for 4 weeks
- Maintenance: 8 mg orally twice daily for at least 4 weeks
- Consider increase to 12 mg orally twice daily if indicated
- Extended Release
- Start: 8 mg orally daily for 4 weeks
- Maintenance: 16 mg orally daily for at least 4 weeks
- Consider increase to 24 mg orally daily if indicated
-
Renal Dosing
- GFR 9 to 59 ml/min: Maximum dose 16 mg/day
- GFR <9 ml/min: Avoid Galantamine
VI. Adverse Effects
- See Acetylcholinesterase Inhibitor
- Cardiovascular
- Gastrointestinal
- Neuropsychiatric
VII. Efficacy
- Moderately preserved cognitive function for >6 months
- References
VIII. Resources
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Related Studies
| galantamine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| GALANTAMINE ER 16 MG CAPSULE | Generic | $1.66 each |
| GALANTAMINE ER 24 MG CAPSULE | Generic | $1.17 each |
| GALANTAMINE ER 8 MG CAPSULE | Generic | $1.11 each |
| GALANTAMINE HBR 12 MG TABLET | Generic | $0.44 each |
| GALANTAMINE HBR 4 MG TABLET | Generic | $0.34 each |
| GALANTAMINE HBR 8 MG TABLET | Generic | $0.66 each |