II. Indication
- Alzheimer's Disease related Dementia
III. Mechanism
- Acetylcholinesterase Inhibitor
- Acts also at Nicotinic Receptors
- Derived from Daffodil bulbs
IV. Pharmacokinetics
V. Dosing
- May require concurrent Antiemetic use
- Immediate Release
- Start: 4 mg orally twice daily with breakfast and dinner for 4 weeks
- Maintenance: 8 mg orally twice daily for at least 4 weeks
- Consider increase to 12 mg orally twice daily if indicated
- Extended Release
- Start: 8 mg orally daily for 4 weeks
- Maintenance: 16 mg orally daily for at least 4 weeks
- Consider increase to 24 mg orally daily if indicated
-
Renal Dosing
- GFR 9 to 59 ml/min: Maximum dose 16 mg/day
- GFR <9 ml/min: Avoid Galantamine
VI. Adverse Effects
- See Acetylcholinesterase Inhibitor
- Cardiovascular
- Gastrointestinal
- Neuropsychiatric
VII. Efficacy
- Moderately preserved cognitive function for >6 months
- References
VIII. Resources
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Related Studies
galantamine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
GALANTAMINE ER 16 MG CAPSULE | Generic | $1.66 each |
GALANTAMINE ER 24 MG CAPSULE | Generic | $1.17 each |
GALANTAMINE ER 8 MG CAPSULE | Generic | $1.11 each |
GALANTAMINE HBR 12 MG TABLET | Generic | $0.44 each |
GALANTAMINE HBR 4 MG TABLET | Generic | $0.34 each |
GALANTAMINE HBR 8 MG TABLET | Generic | $0.66 each |
Ontology: Galantamine (C0016967)
Definition (MSH) | A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D005702 |
SnomedCT | 323377002, 395727007 |
English | Galantamin, Lycoremine, galanthamine, lycoremine, Galantamine [Chemical/Ingredient], galantamin, GALANTAMINE, galantamine, Galanthamine, 6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, Galantamine, Galantamine (product), Galantamine (substance) |
Swedish | Galantamin |
Czech | galanthamin, galantamin |
Finnish | Galantamiini |
Russian | NIVALIN, LIKOREMIN, GALANTAMIN, ГАЛАНТАМИН, ЛИКОРЕМИН, НИВАЛИН |
Japanese | リコレミン, ガランタミン, 臭化水素酸ガランタミン, ガランタミン臭化水素酸塩 |
Croatian | GALANTAMIN |
Polish | Niwalina, Galantamina |
Spanish | galantamina (producto), galantamina (sustancia), galantamina, Galantamina, Licorémina |
French | Galantamine, Galanthamine |
German | Galantamin, Galanthamin, Lycoremin |
Italian | Galantamina |
Portuguese | Galantamina, Licoremina |
Ontology: Razadyne (C0939465)
Definition (MSH) | Name of the FDA approved preparation from J&J. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D005702 |
Czech | reminyl |
German | Reminyl |
English | Razadyne, Ortho McNeil Neurologics Brand of Galantamine, Ortho-McNeil Neurologics Brand of Galantamine, reminyl, Reminyl |
Portuguese | Reminyl |
Spanish | Reminilo |