II. Indications
-
Multiple Sclerosis (relapsing)
- Typically in combination with other MS agents (e.g. Interferon Beta, glatiramir)
III. Mechanism
- Immunomodulatory agent that inhibits Pyrimidine synthesis
- Teriflunomide is an active metabolite of Leflunomide
IV. Medications
- Teriflunomide (Aubagio) tablets: 7 mg, 14 mg
V. Dosing
- Adults: 7 to 14 mg orally once daily
VI. Adverse Effects
- Hepatotoxicity (black-box warning)
- May be severe or fatal, similar to Leflunomide toxicity (uncommon)
- Stop Teriflunomide at the first sign of liver toxicity
- Gastrointestinal
- Neurologic
- Dermatologic
VII. Safety
- Unknown safety in Lactation
- Contraindicated in Pregnancy
- Pregnancy Category X in all trimesters
- Use effective Contraception
- Men and women should not try to conceive until Teriflunomide serum levels are <0.02 mcg/ml
- Monitoring
- Liver Function Tests (at baseline and then every 6 months)
- Complete Blood Count (at baseline and periodically, including with signs infection)
VIII. Resources
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Related Studies
| teriflunomide (on 9/20/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| TERIFLUNOMIDE 14 MG TABLET | Generic | $0.91 each |