II. Indications
- Multiple Sclerosis (relapsing-remitting)
III. Mechanism
- Non-Interferon, immunomodulatory agent
- Structurally similar peptide chain to myelin basic Protein
- Polymer contains random sequence and length of 4 Amino Acids (L-Alanine, L-Glutamate, L-Lysine, L-Tyrosine)
- Acts as a decoy for immune response
IV. Medications
- Glatiramer Acetate (Copaxone, Glatopa) prefilled syringes for SQ Injection: 20 mg/ml or 40 mg/ml
- NOT for IV injection (only SQ Injection)
V. Dosing
- Glatiramer Acetate 20 mg/ml SQ daily OR
- Glatiramer Acetate 40 mg/ml SQ three times weekly (at least 48 hours between doses)
- Rotate injection sites to prevent Lipodystrophy
VI. Adverse Effects
- Local injection site inflammation
- Facial Flushing
- Immediate post-injection
- May be accompanied by chest symptoms
-
Chest symptoms (after first month of treatment, typically self-limited)
- Chest tightness (transient)
- Dyspnea
- Palpitations
- Throat tightness
- Anxiety
VII. Safety
- Pregnancy Category B
- Unknown safety in Lactation
VIII. Efficacy
- Good track record of safety and greater efficacy than Interferon
IX. Resources
- Glatiramer Acetate (DailyMed)
Images: Related links to external sites (from Bing)
Related Studies
glatiramer (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
GLATIRAMER 40 MG/ML SYRINGE | Generic | $131.63 per ml |
copaxone (on 12/20/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
COPAXONE 20 MG/ML SYRINGE | $230.59 per ml | |
COPAXONE 40 MG/ML SYRINGE | Generic | $131.63 per ml |
glatopa (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
GLATOPA 40 MG/ML SYRINGE | Generic | $131.63 per ml |
Ontology: glatiramer acetate (C0289884)
Concepts | Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) |
MSH | C089995 |
SnomedCT | 108755008 |
English | copolymer 1, copolymer-1, glatiramer acetate, glatiramer acetate (medication), hormones glatiramer acetate, L-Glutamic acid peptide with L-alanine, L-lysine and L-tyrosine, acetate (salt), copolymer 1 [Chemical/Ingredient], GLATIRAMER ACETATE, COP-1, Glatiramer acetate, Glatiramer acetate (substance), Glatiramer Acetate |
Spanish | acetato de glatirámero (sustancia), acetato de glatirámero |
Ontology: Glatiramer (C0717787)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
SnomedCT | 108754007, 372535006 |
English | glatiramer, GLATIRAMER, Glatiramer, Glatiramer (product), Glatiramer (substance) |
Spanish | glatirámero (sustancia), glatiramer (sustancia), glatiramer, glatirámero (producto), glatirámero |