Oxcarbazepine

Aka: Oxcarbazepine, Trileptal

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II. Indications

  1. Simple Partial Seizures
  2. Complex Partial Seizures
  3. Generalized Tonic Clonic Seizures
  4. Trigeminal Neuralgia
  5. Mania

III. Adverse Effects: Dose related

  1. Nausea or Vomiting
  2. Dizziness or Vertigo
  3. Headache
  4. Ataxia
  5. Diplopia
  6. Sedation
  7. Lethargy
  8. Tremor
  9. Rash

IV. Adverse Effects: Other

  1. Hyponatremia
  2. Cardiac arrhythmia

V. Dosing

  1. Child (age 4 to 16 years old)
    1. Initial: 8-10 mg/kg/day divided twice daily
    2. May be increased by 5 mg/kg/day up to every 3 days, up to maximum dose
  2. Adult (includes elderly)
    1. Initial: 300 mg (max 600 mg) orally twice daily
    2. Increase by 300 mg/day each week

VI. References

  1. Liu (2017) Am Fam Physician 96(2): 87-96 [PubMed]

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Cost: Medications

oxcarbazepine (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
OXCARBAZEPINE 150 MG TABLET Generic $0.14 each
OXCARBAZEPINE 300 MG TABLET Generic $0.17 each
OXCARBAZEPINE 300 MG/5 ML SUSP Generic $0.44 per ml
OXCARBAZEPINE 600 MG TABLET Generic $0.35 each
trileptal (on 2/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
TRILEPTAL 150 MG TABLET Generic $0.14 each
TRILEPTAL 300 MG TABLET Generic $0.17 each
TRILEPTAL 300 MG/5 ML SUSP Generic $0.44 per ml
TRILEPTAL 600 MG TABLET Generic $0.35 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ontology: oxcarbazepine (C0069751)

Definition (NCI) A dibenzazepine carboxamide derivative with an anticonvulsant property. As a prodrug, oxcarbazepine is converted to its active metabolite, 10-monohydroxy. Although the mechanism of action has not been fully elucidated, electrophysiological studies indicate this agent blocks voltage-gated sodium channels, thereby stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing the propagation of synaptic impulses.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C036006
SnomedCT 323042005, 116511002, 387025007
LNC LP20805-5, MTHU012038
English 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide, oxcarbazepine (medication), OXCARBAZEPINE, oxcarbazepine [Chemical/Ingredient], oxcarbazepine substance, OXcarbazepine, oxcarbazepine, Oxcarbazepine (product), Oxcarbazepine (substance), Oxcarbazepine
Spanish oxcarbacepina, oxcarbazepina (producto), oxcarbazepina (sustancia), oxcarbazepina
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Trileptal (C0876196)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C036006
English trileptal, Novartis brand of oxcarbazepine, Trileptal
Japanese オクスカルバゼピン
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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