II. Indications

  1. Parkinsonism
  2. Restless Leg Syndrome
    1. Moderate to severe symptoms refractory to Pramipexole or Ropinirole

III. Mechanism

  1. Non-ergot Dopamine Agonist available as a transdermal patch

IV. Technique: Patch Application

  1. Apply once daily (available in 1, 2, 3, 4, 6 and 8 mg)
  2. Patch applied daily to a new dry, clean and intact skin site
  3. Hold patch in place for 20-30 seconds before removing hand
  4. Appropriate sites include Abdomen, thigh, flank, Shoulder, upper arm
  5. Wash skin after removal
  6. Do not repeat the same site for 14 days
  7. Remove patch prior to MRI, cardioversion

V. Dosing: Parkinsonism

  1. Start at 2 mg/24 hours
    1. May start a 4 mg/24h patch in advanced Parkinsonism
  2. May increase weekly by 2 mg/24h patch to a maximum of 6 mg/24h (8 mg/24h in advanced Parkinsonism)
  3. Taper patch by 2 mg/24h every 2 days when stopping

VI. Dosing: Refractory Restless Leg Syndrome

  1. Start at 1 mg/24 hours
  2. May increase weekly by 1 mg/24h patch to a maximum of 3 mg/24 hours

VII. Adverse Effects

  1. Pregnancy Category: C
  2. Lactation: Unknown Safety

IX. References

  1. (2021) Med Lett Drugs Ther 63(1618): 25-32
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 46-7
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia

Images: Related links to external sites (from Bing)

Related Studies

Cost: Medications

neupro (on 1/1/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
NEUPRO 1 MG/24 HR PATCH $24.38 each
NEUPRO 2 MG/24 HR PATCH $24.24 each
NEUPRO 3 MG/24 HR PATCH $24.35 each
NEUPRO 4 MG/24 HR PATCH $24.35 each
NEUPRO 6 MG/24 HR PATCH $24.37 each
NEUPRO 8 MG/24 HR PATCH $24.30 each

Ontology: Rotigotine (C1700683)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C047508
SnomedCT 421915002, 421924006
English Rotigotine (product), Rotigotine (substance), ROTIGOTINE, Rotigotine, antiparkinsonism drugs rotigotine (medication), antiparkinsonism drugs rotigotine, rotigotine
Spanish rotigotina (producto), rotigotina (sustancia), rotigotina

Ontology: Neupro (C1949346)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C047508
English Neupro