II. Indications
- Drug-Induced Extrapyramidal Side Effects
- Parkinsonism
III. Contraindications
- Narrow Angle Glaucoma
- Acute Bowel Obstruction
- Megacolon
- Elderly (relative)
- On Beer's List, due to risk of Delirium, pscyhosis, Fall Risk
IV. Mechanism
- Centrally acting Muscarinic Antagonist
- Decreases imbalance of Acetylcholine to Dopamine ratio within corpus striatum (Basal Ganglia)
V. Dosing: Parkinsonism
- Start: 0.5 to 1 mg/day orally, IM or IV divided once at bedtime to four times daily
- Increase by 0.5 mg/day each week as needed
- Maximum: 6 mg/day
VI. Dosing: Extrapyramidal Side Effects
- Acute Dystonic Reaction
- Administer 1 to 2 mg orally, IM or IV
- Chronic
- Start 1 to 4 mg orally, IM or IV once to twice daily
- Consider taper off after 1-2 weeks
VII. Adverse Effects
- See Anticholinergic Symptoms
- Avoid in pregnancy (may be Teratogenic)
- Unknown safety in Lactation
- Withdrawal symptoms with severe increase in Parkinsonism symptoms
- Titrate medication off without abruptly stopping
VIII. Resources
IX. References
- (2021) Med Lett Drugs Ther 63(1618): 25-32
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 46-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
benztropine (on 4/5/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
BENZTROPINE MES 0.5 MG TAB | Generic | $0.08 each |
BENZTROPINE MES 1 MG TABLET | Generic | $0.08 each |
BENZTROPINE MES 2 MG TABLET | Generic | $0.11 each |
Ontology: Benztropine (C0005098)
Definition (MSH) | A centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine. |
Definition (CSP) | centrally active muscarinic antagonist that has been used in the symptomatic treatment of Parkinson disease; also inhibits the uptake of dopamine. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D001590 |
SnomedCT | 372846002, 77390008 |
LNC | LP17858-9, MTHU019541 |
English | Benztropine, 8-Azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-8-methyl-, endo-, Benzatropine, Benztropine [Chemical/Ingredient], BENZTROPINE, benzatropine, benztropine, Benztropine (product), Benztropine (substance) |
Swedish | Benstropin |
Czech | benztropin |
Finnish | Bentstropiini |
Russian | BENZTROPIN, БЕНЗТРОПИН |
Japanese | ベンズトロピン, コゲンチン, ベンズアトロピン |
Polish | Benzatropina |
Spanish | benzotropina, benztropina (producto), benztropina (sustancia), benztropina, Benzotropina |
French | Benzatropine |
German | Benzatropin |
Italian | Benztropina |
Portuguese | Benzotropina |
Ontology: Cogentin (C0591275)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D001590 |
German | Cogentin |
English | cogentin, Cogentin |