II. Indications

  1. Drug-Induced Extrapyramidal Side Effects
  2. Parkinsonism
    1. Adjunctive, symptomatic management of Tremor or Drooling

III. Contraindications

  1. Narrow Angle Glaucoma
  2. Acute Bowel Obstruction
  3. Megacolon
  4. Elderly (relative)
    1. On Beer's List, due to risk of Delirium, pscyhosis, Fall Risk

IV. Mechanism

  1. Centrally acting Muscarinic Antagonist
  2. Decreases imbalance of Acetylcholine to Dopamine ratio within corpus striatum (Basal Ganglia)

V. Dosing: Parkinsonism

  1. Start: 0.5 to 1 mg/day orally, IM or IV divided once at bedtime to four times daily
  2. Increase by 0.5 mg/day each week as needed
  3. Maximum: 6 mg/day

VI. Dosing: Extrapyramidal Side Effects

  1. Acute Dystonic Reaction
    1. Administer 1 to 2 mg orally, IM or IV
  2. Chronic
    1. Start 1 to 4 mg orally, IM or IV once to twice daily
    2. Consider taper off after 1-2 weeks

VII. Adverse Effects

  1. See Anticholinergic Symptoms
  2. Avoid in pregnancy (may be Teratogenic)
  3. Unknown safety in Lactation
  4. Withdrawal symptoms with severe increase in Parkinsonism symptoms
    1. Titrate medication off without abruptly stopping

IX. References

  1. (2021) Med Lett Drugs Ther 63(1618): 25-32
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 46-7
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Cost: Medications

benztropine (on 4/5/2023 at Medicaid.Gov Survey of pharmacy drug pricing)
BENZTROPINE MES 0.5 MG TAB Generic $0.08 each
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BENZTROPINE MES 2 MG TABLET Generic $0.11 each