II. Causes: Organophosphate Poisoning
- Management: See Organophosphate Poisoning Management
- Mechanism
- Irreversibly inhibits Cholinesterase
- Results in Cholinergic Toxicity
-
Pesticides
- Acephate (Orthene)
- Chlorphoxim (Baythion-C)
- Chlorpyrifos (Dursban, Lorsban)
- Diazinon
- Dimethoate (Cygon, Defend)
- Ethoprop (Mocap)
- Fenitrothion (Sumithion)
- Fenthion (Baytex)
- Malathion (Cythion)
- Naled (Dibrome)
- Terbufos (Counter)
- Other Organophosphate agents
- Triorthocresyl phosphate (TOCP)
- Used in hydraulic fluids, lubricants, plastics
- May contaminate foods and result in Neuropathy
- Triorthocresyl phosphate (TOCP)
III. Causes: Carbamate Poisoning
- Mechanism
- Reversible Cholinesterase inhibition
- Results in Cholinergic Toxicity
- Less severe toxicity than with Organophosphates
- Management
- Similar to Organophosphate Poisoning Management
- 2-PAMCl not indicated unless mixed exposure
-
Pesticides
- Carbaryl (Sevin)
- Primicarb (Aphox, Rapid)
- Propoxur (Baygon)
- Timethacarb (Landrin)
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Definition (MSH) | Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid. |
Definition (CSP) | carbamic acid, its salts or esters; contains the general formula NH2-COO-. |
Concepts | Organic Chemical (T109) |
MSH | D002219 |
SnomedCT | 79522001, 406748003 |
LNC | LP19594-8, MTHU008703 |
Swedish | Karbamater |
Czech | karbamáty, pentakain |
Finnish | Karbamaatit |
Russian | KARBAMATY, КАРБАМАТЫ |
English | Carbamates, Carbamates [Chemical/Ingredient], carbamates, carbamate, Carbamate, Carbamate (substance), Carbamates, NOS |
Croatian | Not Translated[Carbamates] |
Polish | Karbaminiany |
Norwegian | Not Translated[Carbamates] |
Spanish | carbamatos, carbamato (sustancia), carbamato, Carbamatos |
French | Carbamates |
German | Carbamate |
Italian | Carbammati |
Portuguese | Carbamatos |
Ontology: Phosphoric Acid Esters (C0031701)
Definition (NCI_NCI-GLOSS) | A form of phosphoric acid, which contains phosphorus. In the body, phosphates are found in the bones and teeth. Phosphates may be used to treat a high level of calcium in the blood. Adding or removing phosphate chemical groups may affect the way proteins act in the body. |
Definition (NCI) | An ester of phosphoric acid, which contains phosphorus. Organic phosphates play important roles in biochemistry and biogeochemistry or ecology. |
Definition (MSH) | Organic esters of phosphoric acid. |
Definition (CSP) | organic esters of phosphoric acid. |
Concepts | Organophosphorus Compound (T115) |
MSH | D010755 |
SnomedCT | 50352000, 301785006 |
English | Acid Esters, Phosphoric, Esters, Phosphoric Acid, Organic Phosphates, Phosphates, Organic, phosphoric ester, PHOSPHATES ORG, organophosphate, organic phosphates, organophosphates, organic phosphate, Organic Phosphate, Phosphoric Acid Esters, Organophosphates [Chemical/Ingredient], Organophosphates, phosphate, Organic phosphate, Organophosphate, Phosphoric acid ester, Phosphoric acid ester (substance), Organic phosphate, NOS, Organophosphate, NOS |
Swedish | Fosforsyraestrar |
Finnish | Fosforihappoesterit |
Italian | Fosfati organici, Esteri dell'acido fosforico |
Japanese | 有機リン酸塩, 有機リン酸, りん酸エステル, 有機りん酸塩, 燐酸エステル, リン酸エステル |
Czech | estery kyseliny fosforečné |
French | Phosphates organiques, Esters de l'acide phosphorique |
German | Phosphorsäureester, Phosphate, organische |
Spanish | Ésteres del Ácido Fosfórico, éster de ácido fosfórico (sustancia), éster de ácido fosfórico, Fosfatos Orgánicos |
Portuguese | Ésteres do Ácido Fosfórico, Fosfatos Orgânicos |
Ontology: Organophosphate poisoning (C0700359)
Definition (MSH) | Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES. |
Concepts | Injury or Poisoning (T037) |
MSH | D062025 |
SnomedCT | 88041008, 8260003, 71597002 |
English | Organophosphate poisoning, Orgnphos insectcd caus tox eff, poisoning by organophosphorus insecticides (diagnosis), poisoning by organophosphorus insecticides, organophosphate poisoning, organophosphate poison, organophosphate toxicity, phosphate organic poisoning, organic phosphate poisoning, organophosphates poisoning, Organophosphate Poisonings, Poisoning, Organophosphate, Organophosphate Poisoning, Poisonings, Organophosphate, Organophosphate Poisoning [Disease/Finding], poisoning by organophosphate, poisoning by organophosphate insecticides (diagnosis), poisoning by organophosphate insecticides, Organophosphate intoxication, Organic phosphate poisoning, Organophosphate insecticide poisoning, Organophosphate toxicity, Organophosphate insecticide causing toxic effect, Organophosphate poisoning (disorder) |
Czech | otrava organofosfáty |
French | Empoisonnement par des organophosphates, Intoxication aux organophosphates, Intoxication par des organophosphates |
German | Organophosphatvergiftung, Organophosphat-Vergiftung |
Italian | Avvelenamento da organofosfati |
Polish | Zatrucie fosforanami organicznymi |
Russian | OTRAVLENIE ORGANICHESKIMI FOSFATAMI, ОТРАВЛЕНИЕ ОРГАНИЧЕСКИМИ ФОСФАТАМИ, ORGANOTIOFOSFONATAMI OTRAVLENIE, ОРГАНОТИОФОСФОНАТАМИ ОТРАВЛЕНИЕ, ORGANOFOSFATAMI OTRAVLENIE, FOSFORORGANICHESKIMI SOEDINENIIAMI OTRAVLENIE, ORGANOTIOFOSFATAMI OTRAVLENIE, ОРГАНОФОСФАТАМИ ОТРАВЛЕНИЕ, ФОСФОРОРГАНИЧЕСКИМИ СОЕДИНЕНИЯМИ ОТРАВЛЕНИЕ, ОРГАНОТИОФОСФАТАМИ ОТРАВЛЕНИЕ |
Portuguese | Intoxicação por Organofosfatos |
Norwegian | Organofosfatforgiftning |
Spanish | Intoxicación por Organofosfatos, Intoxicación por Organofosfato, intoxicación por fosfato orgánico, intoxicación por insecticida organofosforado, intoxicación por organofosforados (trastorno), intoxicación por organofosforados |