II. Mechanism
III. Indications
IV. Contraindications
- Pregnancy
- Hepatic dysfunction
- Hematologic disorders
V. Dosing
- Therapeutic Level: 15 to 50 mcg/ml
- Adults
- Start up to 1000 mg/day divided in 4 to 6 doses after meals
- Target: 2000 to 3000 mg/day in divided doses
- Children
- Start up to 750 mg/day divided in 4 to 6 doses after meals
- Target: 500 to 1000 mg/day in divided doses
- Maximum: 2000 to 3000 mg/day in divided doses
VI. Metabolism
- Hepatic Metabolism
VII. Safety
- Pregnancy Category X (Known Teratogen)
- Unknown Safety in Lactation
- Secreted into Breast Milk
- Monitoring (periodic recheck)
VIII. Resources
IX. References
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
Definition (NCI) | A hydantoin anticonvulsant with anti-epileptic activity. The mechanism of action is not completely known, but is thought to be fairly similar to phenytoin. Ethotoin influences synaptic transmission by altering sodium and calcium ion influx across neuronal membranes in the repolarization, depolarization, and membrane stability phase and interferes with the calcium uptake in presynaptic terminals. This inhibits neuronal firing and results in the stabilization of neuronal membranes, thereby preventing the spread of seizure activity at the motor cortex. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C084606 |
SnomedCT | 64463006, 371384002 |
LNC | LP16138-7, MTHU016713 |
English | ethotoin, 2,4-Imidazolidinedione, 3-ethyl-5-phenyl-, 3-ethyl-5-phenyl-2,4-imidazolidinedione, Hydantoin, 3-ethyl-5-phenyl-, ethotoin (medication), ETHOTOIN, ethotoin [Chemical/Ingredient], Ethylphenylhydantoin, Ethotoin (substance), Ethotoin product (product), Ethotoin product, Ethotoin |
Spanish | etotoína (producto), etotoína, producto (producto), etotoína, producto, etilfenilhidantoína, etotoína (sustancia), etotoína |
Ontology: Peganone (C0702073)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C084606 |
English | Peganone, Abbott brand of ethotoin |