II. Indications
- Adjunctive management of Partial Seizures
- Add to primary antiepileptic regimens
- Other potential uses currently being researched
- Myoclonic Seizures
- Infantile Spasm
- Atypical Absence Seizure
- Generalized Tonic Clonic Seizures
III. Pharmacology
IV. Drug Interactions
- Increased Zonisamide clearance with CYP3A4 inducers
- Concurrent carbonic anhydrase inhibitor (Topamax)
- Increased Nephrolithiasis risk
V. Adverse effects
- Dizziness
- Ataxia
- Somnolence
- Nausea
- Anorexia
- Abdominal Pain
- Insomnia
- Impaired cognition
- Confusion
- Decreased concentration
- Speech problems
- Psychosis
- Nephrolithiasis
- Rash
- Stevens Johnson Syndrome
- Toxic Epidermal Necrolysis
- Childhood Adverse Effects
- Oligohydrosis
- Hyperthermia (and Heat Stroke)
VI. Contraindications
- Sulfonamide Allergy
- Pregnancy (Teratogenic in animals)
VII. Dosing: Adults
- Initial: 100 mg PO qd
- Increase: 100 mg every two weeks as needed
- Maximum: 600 mg/day divided qd-bid
- Caution: Increase more slowly in Renal Insufficiency
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Related Studies
zonisamide (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
ZONISAMIDE 100 MG CAPSULE | Generic | $0.12 each |
ZONISAMIDE 25 MG CAPSULE | Generic | $0.08 each |
ZONISAMIDE 50 MG CAPSULE | Generic | $0.09 each |