Medication Causes of Neuropathy

Aka: Medication Causes of Neuropathy, Drug-Induced Polyneuropathy, Peripheral Neuropathy Due to Medications

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II. Causes (Axonal and sensory effects unless otherwise noted)

  1. Neuropsychiatric Medications
    1. Amitriptyline
    2. Levodopa
    3. Lithium (sensorimotor)
    4. Phenytoin
  2. Antimicrobial Medications
    1. Antiretrovirals
    2. Chloroquine (demyelinating)
    3. Dapsone
    4. Didanosine
    5. Ethambutol
    6. Interferon alfa
    7. Isoniazid
    8. Nitrofurantoin (sensorimotor)
    9. Metronidazole
    10. Stavudine
    11. Antifungal Triazoles (e.g. Fluconazole)
  3. Cardiovascular Medications
    1. Amiodarone (sensorimotor)
    2. Digoxin
    3. Hydralazine
    4. Procainamide (demyelinating)
    5. Statins (e.g. Simvastatin)
  4. Chemotherapy Medications
    1. Bortezomib (Velcade)
    2. Cisplatin
    3. Oxaliplatin
    4. Paclitaxel
    5. Thalidomide
    6. Vincristine (sensorimotor)
  5. Heavy Metals
    1. Arsenic Poisoning
    2. Gold
    3. Lead Poisoning
    4. Mercury Poisoning
    5. Thallium
  6. Other Toxins
    1. Acrylamide
    2. Carbon Disulfide
    3. Ethylene Oxide
  7. Miscellaneous
    1. Cimetidine
    2. Colchicine
    3. Disulfiram
    4. Misoprostol or Cytotec (motor)

III. References

  1. Azhary (2010) Am Fam Physician 81(7): 887-92 [PubMed]
  2. Castelli (2020) Am Fam Physician 102(12): 732-9 [PubMed]

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