II. Causes: Proximal or distal sensorimotor Neuropathy (Type 1)

  1. Acute Inflammatory Demyelinating Polyneuropathy
    1. Guillain-Barre Syndrome
  2. Chronic Inflammatory Demyelinating Polyneuropathy
  3. Primary Myelinopathy
  4. Malignancy
  5. HIV or AIDS
  6. Hepatitis B
  7. Buckthorn
  8. Diphtheria

III. Causes: Distal sensorimotor Polyneuropathy or DSPN (Type 2)

  1. Diabetic Neuropathy (Diabetic DSPN)
  2. Alcoholism induced Neuropathy (Alcoholic DSPN)
  3. HIV or AIDS
  4. Malignancy (paraneoplastic syndrome)
  5. Charcot-Marie-Tooth
  6. Toxins
    1. Acrylamide
    2. Allyl chloride
    3. Carbon disulfide
    4. Ethylene oxide
    5. Hexacarbons
    6. Trichloroethylene
    7. OPIDP, PCBs, PNU
    8. Organophosphates
    9. Nitrous Oxide Abuse (due to secondary Vitamin B12 Deficiency)
  7. Metals
    1. Arsenic
    2. Lead Poisoning
    3. Gold
    4. Mercury
    5. Thallium
  8. Medications
    1. See Drug-Induced Polyneuropathy
  9. Vitamin Deficiency
    1. Thiamine deficiency (Beriberi)
    2. Niacin Deficiency (Pellagra)
    3. Vitamin B12 Deficiency (Pernicious Anemia)
    4. Nitrous Induced Subacute Combined Degeneration of the Spinal Cord
    5. Vitamin B6 deficiency
  10. Paraproteinemia
    1. Amyloidosis
    2. Multiple Myeloma
    3. Waldenstrom's Macroglobulinemia
  11. Miscellaneous causes
    1. Acromegaly
    2. Chronic lung disease
    3. Hypothyroidism
    4. Renal Failure
    5. Porphyria
    6. Chronic Liver Disease
    7. Tic Paralysis

IV. References

  1. Gallagher in Marx (2002) Rosen's Emergency Med, p. 1506
  2. Pryse-Phillips in Noble (2001) Primary Care, p. 1579

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Ontology: Polyneuropathy (C0152025)

Definition (CHV) a nerve disease where many peripheral nerves are affected
Definition (CHV) a nerve disease where many peripheral nerves are affected
Definition (MSH) Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
Concepts Disease or Syndrome (T047)
MSH D011115
ICD10 G62.9 , A69.22
SnomedCT 42345000, 193204000, 193166009, 194530007, 307326004, 267706009, 155080009
English Polyneuropathy, Polyneuropathy, unspecified, [X]Polyneuropathy, unspecified, Polyneuropathy unspecified, polyneuropathy (diagnosis), polyneuropathy, Polyneuropathy NOS, Polyneuropathies, Polyneuropathies [Disease/Finding], polyneuropathies, Polyneuropathy (multiple nerve disorder), [X]Polyneuropathy, unspecified (disorder), Polyneuropathy unspecified (disorder), Polyneuropathy (disorder), neuropathy; multiple, Polyneuropathy, NOS
Italian Polineuropatia, Polineuropatia NAS, Polineuropatie
Dutch polyneuropathie NAO, neuropathie; multipel, Polyneuropathie, niet gespecificeerd, polyneuropathie, Neuropathie, poly-, Polyneuropathie
French Polyneuropathie SAI, Polyneuropathie, Neuropathies multiples, Polyneuropathies
German Polyneuropathie NNB, Polyneuropathie, nicht naeher bezeichnet, Polyneuropathie, Polyneuropathien
Portuguese Polineuropatia NE, Polineuropatia, Polineuropatias
Spanish Polineuropatía NEOM, polineuropatía no especificada (trastorno), polineuropatía (trastorno de múltiples nervios), [X]polineuropatía, no especificada, polineuropatía no especificada, [X]polineuropatía, no especificada (trastorno), polineuropatía (trastorno), polineuropatía, Polineuropatía, Polineuropatías
Swedish Polyneuropatier
Czech polyneuropatie, polyneuritida, Polyneuropatie, Polyneuropatie NOS
Finnish Polyneuropatiat
Japanese タハツニューロパチー, 多発ニューロパチーNOS, タハツニューロパチーNOS, 神経障害-多発性, 多発神経炎, 多発神経障害, 多発性ニューロパシー, ポリニューロパチー, 多発ニューロパチー, 多発性ニューロパチー, 多発性神経炎, 多発ニューロパシー, ポリニューロパシー, 多発性神経障害, ニューロパチー-多発, 神経炎-多発性
Korean 상세불명의 다발 신경병증
Polish Zapalenie wielonerwowe, Choroby wielonerwowe, Polineuropatie
Hungarian Polyneuropathia, Polyneuropathia k.m.n.
Norwegian Polynevropatier