Acute Motor Weakness Causes

Aka: Acute Motor Weakness Causes, Emergent Bilateral Motor Weakness, Weakness of Acute Onset

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II. Causes: Autoimmune

  1. Myasthenia Gravis
  2. Lambert-Eaton Syndrome
  3. Polymyositis
  4. Amyotrophic Lateral Sclerosis
  5. Demyelinating Disease
    1. Guillain-Barre Syndrome
    2. Chronic Inflammatory Demyelinating Polyneuropathy

III. Causes: Toxin (See Also Biological Neurotoxin)

  1. Botulism
  2. Buckthorn
  3. Seafood
    1. Paralytic Shellfish toxin
    2. Tetrodotoxin
  4. Tick Paralysis
  5. Compound exposures
    1. Arsenic Poisoning
    2. Thallium (found in rodenticides)
      1. Nausea and Vomiting
      2. Altered Level of Consciousness
      3. Seizures
    3. Lead Poisoning
    4. Organophosphate Poisoning
    5. n-Hexane
  6. Medications
    1. Dapsone

IV. Causes: Metabolic

  1. Thyrotoxicosis
  2. Hypophosphatemia
  3. Hypermagnesemia
  4. Porphyria
  5. Hypokalemia (e.g. Hypokalemic Periodic Paralysis)

V. Causes: Infectious

  1. Acute Flaccid Myelitis
  2. Poliomyelitis
  3. Diphtheria
  4. West Nile Virus

VI. Causes: Miscellaneous

  1. Cervical Spine Injury
  2. Thoracolumbar Injury
  3. Spinal Cord Syndrome
  4. Conversion Disorder

VII. References

  1. Gallagher in Marx (2002) Rosen's Emergency Med, p. 1510
  2. Pryse-Phillips in Noble (2001) Primary Care, p. 1589

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