II. Associated Conditions

  1. Cancer (esp. Small Cell Lung Cancer) in 50% of cases

III. Pathophysiology

  1. Similar to Myasthenia Gravis (in that Acetylcholine is not functional at Synapse)
  2. Calcium channel antibodies block Acetylcholine release from presynaptic terminals

IV. Symptoms

  1. Proximal Muscle Weakness and Fatigue (better with use)
    1. Thighs and hips are most affected (contrast with initial bulbar symptoms of myasthenia)

V. Management

  1. Plasmaphoresis
  2. Tumor resection
  3. Avoid provocative agents
    1. Neuromuscular blocking agents
    2. Aminoglycosides
    3. Intravenous Contrast dye

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