II. Indications
- Ptosis evaluation in suspected Myasthenia Gravis
III. Contraindications
- Elderly
- Coronary Artery Disease
- Asthma
IV. Adverse Effects
- Increased Salivation
- Abdominal cramping
- Bradycardia
- Syncope
- Bronchospasm
V. Mechanism
- Edrophonium (Tensilon) is a rapid onset, short acting Acetylcholinesterase Inhibitor
VI. Preparation
- Perform with telemetry monitoring
- Atropine 0.5 mg IV prn Symptomatic Bradycardia
VII. Technique
- Edrophonium (10 mg/ml) 1 ml is drawn into a 1 cc syringe (tuberculin syringe)
- Inject edrophonium 2 mg (0.2 cc) IV every minute up to cummulative dose of 10 mg
- Stop when improvement in Ptosis is observed or 10 mg is reached (typically at 4-6 mg or 0.4 to 0.6 cc)
VIII. Interpretation
- Ptosis improvement with edrophonium is suggestive of Myasthenia Gravis
IX. Efficacy
- Test Sensitivity: 80-90%
-
False Positives
- Motor Neuron disorders
- Brainstem tumor
- Compressive cranial Neuropathy
X. References
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Related Studies
| Concepts | Diagnostic Procedure (T060) |
| SnomedCT | 33981001 |
| Italian | Test all'edrofonio cloruro |
| English | Tensilon test, Tensilon test (procedure), tensilon test, Edrophonium chloride test for myasthenia gravis, Tensilon test for myasthenia gravis, Edrophonium chloride test for myasthenia gravis (procedure), Edrophonium chloride test for myasthenia gravis (regime/therapy) |
| Japanese | テンシロン試験, ﾃﾝｼﾛﾝｼｹﾝ |
| Spanish | prueba del cloruro de edrofonio para miastenia grave (régimen/tratamiento), prueba de Tensilon para la miastenia grave, prueba del cloruro de edrofonio para miastenia grave, Prueba con Tensilon, prueba del cloruro de edrofonio para miastenia grave (procedimiento) |
| Czech | Test s podáváním přípravku Tensilon |
| Hungarian | Tensilon vizsgálat |
| Portuguese | Teste com Tensilon |
| Dutch | tensilon test |
| French | Epreuve au tensilon |
| German | Tensilon-Test |
