II. Epidemiology

  1. Autosomal Dominant inherited disease
  2. Onset of symptoms in middle life

III. Symptoms

  1. Gradual onset and progression of symptoms
    1. Failing memory
    2. Restlessness
    3. Lack of initiative

IV. Signs

  1. Choreiform movements
  2. Shuffling gait
  3. Mental deterioration
  4. Deep Tendon Reflexes
    1. Normal or increased

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