II. Indication
- Second line Tuberculosis management agent
- Second line agent in Pneumocystis carinii Pneumonia
- First line in certain autoimmune Bullous Conditions
- Other indications
III. Contraindications
IV. Dosing
-
PCP Pneumonia prophylaxis and treatment
- Dapsone 100 mg orally daily
- Combine with other agents (e.g. trimethoprim) for treatment
V. Adverse Effects
- Nausea or Vomiting
- Peripheral Neuropathy (rare)
- Hepatotoxicity
- Blood dyscrasias
- Hemoglobin decreased (1-2 grams)
- Reticulocytes increased (2-12%)
- Hemolysis in G6PD Deficiency
- Methemoglobinemia
- Renal effects
- Proteinuria or Albuminuria
- Nephrotic Syndrome
- Skin effects
- Photosensitivity (Sunburn risk)
- Erythema Nodosum leprosum in Leprosy treatment (50%)
VI. Safety
- Pregnancy Category C
- Unknown safety in Lactation
VII. Monitoring
-
Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD)
- Screen for G6PD Deficiency before starting Dapsone
-
Complete Blood Count
- Obtain baseline and monthly for at least 6 months (then twice yearly) while on Dapsone
-
Liver Function Tests
- Obtain periodic levels
VIII. Resources
- Dapsone Tablet (DailyMed)
Images: Related links to external sites (from Bing)
Related Studies
| dapsone (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| DAPSONE 100 MG TABLET | Generic | $1.02 each |
| DAPSONE 25 MG TABLET | Generic | $0.57 each |
| DAPSONE 5% GEL | Generic | $3.56 per gram |
| DAPSONE 7.5% GEL PUMP | Generic | $2.28 per gram |