II. Causes: Proximal and Distal Sensorimotor Asymmetric Neuropathy (Type 3)

  1. Radiculopathy (e.g. Lumbar Disc Disease)
  2. Plexopathy
    1. Brachial (e.g. Stinger, Thoracic Outlet Syndrome)
    2. Lumbosacral (e.g. HSV, VZV, CMV, HIV)

III. Causes: Distal Asymmetric Neuropathy

IV. Causes: Focal Neuropathy (Mononeuropathy)

  1. Characteristics
    1. Primarily sensory Neuropathy (e.g. pain and Paresthesias)
    2. Motor symptoms (e.g. Muscle Weakness, atrophy) occur in severe or chronic cases
  2. Causes
    1. Acromegaly
    2. Amyloidosis
    3. Cancer infiltration
    4. Direct nerve Trauma (e.g. Burn Injury, frost bite, Radiation Injury, traction)
    5. Entrapment Neuropathy
    6. Ischemic injury
    7. Leprosy
    8. Myxedema (Hypothyroidism)
    9. Rheumatoid Arthritis
    10. Sarcoidosis

V. Causes: Multifocal Neuropathy (Mononeuropathy Multiplex)

  1. Characteristics
    1. Asymmetric, multifocal sensory (pain, Paresthesias, proprioception), motor (weakness, atrophy) deficits
    2. Autonomic deficits may occur
  2. Causes
    1. Connective Tissue Disorders and Vasculitis
    2. Diabetes Mellitus
    3. Hereditary predisposition to Compression Neuropathy
    4. HIV Infection or AIDS
    5. Leprosy

VI. References

  1. Gallagher in Marx (2002) Rosen's Emergency Med, p. 1506
  2. Pryse-Phillips in Noble (2001) Primary Care, p. 1579
  3. Castelli (2020) Am Fam Physician 102(12): 732-9 [PubMed]

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Ontology: Mononeuropathies (C0494491)

Definition (MSH) Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ISCHEMIA; traumatic injury; compression; CONNECTIVE TISSUE DISEASES; CUMULATIVE TRAUMA DISORDERS; and other conditions.
Concepts Disease or Syndrome (T047)
MSH D020422
ICD10 G58.9
SnomedCT 304595001, 128189008
English Mononeuropathy, unspecified, Mononeuropathy NOS, Mononeuropathies, Mononeuropathies [Disease/Finding], mononeuropathy, mononeuropathies, Mononeuropathy, Mononeuropathy (disorder)
Italian Mononeuropatia, Mononeuropatia NAS, Mononeuropatie
Dutch mononeuropathie NAO, Mononeuropathie, niet gespecificeerd, mononeuropathie, mononeuropathieën, Mononeuropathie, Mononeuropathieën
French Mononeuropathie SAI, Mononeuropathie, Mononeuropathies
German Mononeuropathie NNB, Mononeuropathie, nicht naeher bezeichnet, Mononeuropathie, Mononeuropathien
Portuguese Mononeuropatia NE, Mononeuropatia, Mononeuropatias
Spanish Mononeuropatía NEOM, mononeuropatía (trastorno), mononeuropatía, Mononeuropatía, Mononeuropatías
Swedish Mononeuropatier
Czech mononeuritis multiplex, mononeuropatie, Neuropatie jednoho nervu, Mononeuropatie NOS, Mononeuropatie
Finnish Mononeuropatiat
Japanese 単ニューロパチーNOS, タンニューロパチー, 単ニューロパチー, タンニューロパチーNOS, マルチプルモノニューロパシー, モノニューロパシー-多発, 多発性モノニューロパシー, 単ニューロパシー, 単ニューロパシー-多発, 単ニューロパシー-多発性, 神経疾患-単神経性, 多発単神経, 多発モノニューロパシー, 単神経性ニューロパシー, 神経障害-単神経性, 多発単ニューロパシー, 単神経症, マルチプル・モノニューロパシー, 単神経炎-多発性, ニューロパシー-単神経性, 単神経炎, 多発性単ニューロパシー, 単発神経障害, 単発ニューロパシー, モノニューロパシー-多発性, 散発ニューロパシー, モノニューロパシー, 多発性単神経炎, 散発性ニューロパシー, 単神経障害
Korean 상세불명의 단발 신경병증
Croatian Not Translated[Mononeuropathies]
Polish Mononeuropatie
Hungarian Mononeuropathia k.m.n., Mononeuropathiák, Mononeuropathia
Norwegian Mononevropatier

Ontology: Mononeuropathy Multiplex (C0740343)

Concepts Disease or Syndrome (T047)
MSH D020422
Czech mononeuropatie mnohočetná, Mononeuritis multiplex
Portuguese Mononeuropatia Múltipla, Mononeuropatia múltipla
Spanish Mononeuropatía Múltiple, Mononeuropatía múltiple
French Mononeuropathies multiples, Mononeuropathie multiple
German Multiplexe Mononeuropathie, Mononeuropathie multiplex
Japanese 多発性単ニューロパチー, タハツセイタンニューロパチー
English Mononeuropathy multiplex, Mononeuropathy Multiplex Syndrome, Mononeuropathy Multiplex Syndromes, Syndrome, Mononeuropathy Multiplex, Syndromes, Mononeuropathy Multiplex, mononeuropathy multiplex, Mononeuropathy Multiplex
Hungarian Multiplex mononeuropathia
Norwegian Mononevropati multiplex, Mononeuropathia multiplex
Italian Mononeuropatia multipla
Dutch mononeuropathie multiplex, Mononeuropathie, multipele