Definition (NCI_NCI-GLOSS)
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A drug that belongs to the family of drugs called nucleoside analogues. It is used to treat infection caused by viruses.
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Definition (NCI)
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A nucleoside reverse transcriptase inhibitor analog of thymidine. Stavudine has been recommended to undergo phase-out management due to its long-term, irreversible side-effects.
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Definition (CSP)
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nucleoside analog; used as an antiviral agent.
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Definition (MSH)
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A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
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Definition (PDQ)
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A synthetic nucleoside, analog of didehydro-3-deoxythymidine with potent antiretroviral activity. In vivo, stavudine is phosphorylated by cellular kinases to the active metabolite stavudine triphosphate; this metabolite inhibits the activity of HIV reverse transcriptase both by competing with the natural substrate deoxythymidine triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack the essential 3'-OH group). Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41064&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41064&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1428" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Nucleic Acid, Nucleoside, or Nucleotide
(T114)
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MSH |
D018119
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SnomedCT |
108690008, 386895008 |
LNC |
LP21315-4, MTHU013858 |
English |
D4T, Stavudine, 2',3'-Didehydro-2',3'-dideoxythmidine, 2',3'-Didehydro-3'-deoxythymidine, 2',3' Didehydro 3' deoxythymidine, Thymidine, 2',3'-didehydro-3'-deoxy-, 3'-Deoxy-2'-thymidinene, 1-(2,3-Dideoxy-beta-glycero-pent-2-enofuranosyl)thymine, stavudine, DIDEHYDRODEOXYTHYMIDINE 02 03 03, D A 004 T, Dideoxydidehydrothymidine, 2'3' didehydro 3' deoxythymidine, 2'3' didehydrodeoxythymidine, stavudine (medication), STAVUDINE, Stavudine [Chemical/Ingredient], d4t, Stavudine (product), Stavudine (substance), dideoxydidehydrothymidine, didehydrodeoxythymidine, d4T, Didehydrodeoxythymidine, STAVUDINE (d4T) |
German |
2,3-Didehydro-3-Desoxythymidin, DIDEHYDRODESOXYTHYMIDIN 02 03 03, D A 004 T, 2',3'-Didehydro-3'-Desoxythymidin, D4T, Stavudin |
Swedish |
Stavudin
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Czech |
stavudin
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Finnish |
Stavudiini
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Russian |
STAVADIN, STAVUDIN, DEGIDRODEZOKSITIMIDIN, 2',3'-DIDEGIDRO-3'-DEZOKSITIMIDIN, D4T, 2',3'-ДИДЕГИДРО-3'-ДЕЗОКСИТИМИДИН, ДЕГИДРОДЕЗОКСИТИМИДИН, СТАВАДИН, СТАВУДИН |
Japanese |
サニルブジン, スタブジン, 2',3'-ジデヒドロ-3'-デオキシチミジン |
Polish |
Stawudyna, D4T |
Portuguese |
2',3'-Didesidro-3'-desoxitimidina, D4T, Estavudina |
Spanish |
estavudina (producto), estavudina (sustancia), estavudina, D4T, 2',3'-Didehidro-3'-desoxitimidina, Estavudina |
French |
2,3'-didehydro-3'-deoxythymidine, d4T, Stavudine |
Italian |
Stavudina
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